Document Detail

Topical metronidazole can reduce pain after surgery and pain on defecation in postoperative hemorrhoidectomy.
MedLine Citation:
PMID:  18176825     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Topical metronidazole (10 percent) has been previously demonstrated to decrease postoperative pain after hemorrhoidectomy. The aim of this study was to evaluate the effect of topical metronidazole (10 percent) in reducing postoperative and after-defecation pain of hemorrhoidectomy. MATERIALS AND METHODS: A double-blind, randomized trial was conducted to compare posthemorrhoidectomy pain with use of topical metronidazole (10 percent) vs. placebo carrier, applied to surgical site. Forty-seven patients were randomly allocated to receive metronidazole (n=25) or placebo (n=22). Pain was assessed using a visual analog scale preoperatively and on postoperative hours 6 and 12 and at days 1, 2, 7, and 14. The use of narcotic, additional analgesics, and complications were recorded. (Pain scores were calculated and compared with baseline values and control group (t test, SPSS ver.10). RESULTS: Patients in the topical metronidazole group had significantly less postoperative pain than those in the placebo group up to day 14 (P <or= 0.04). There was no significant difference in narcotic analgesic requirements between groups, except on hour 12 (P<0.05). In the metronidazole group, after-defecation pain was ranked significantly lower at day 2 (P=0.016) and patients required fewer additional analgesics postoperatively on days 2 and 7 (P <or= 0.04). CONCLUSION: These finding indicate that topical 10 percent metronidazole significantly reduce posthemorrhoidectomy discomfort, and postoperative defecation pain is reduced compared with that of the placebo control group.
Shahram Ala; Majid Saeedi; Fariborz Eshghi; Parastou Mirzabeygi
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-01-04
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  51     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-07     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
Faculty of Pharmacy, Clinical Pharmacy, Mazandaran University of Medical Sciences, P.O. Box 48175-861, Sari, Mazandaran Province, Iran.
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MeSH Terms
Administration, Topical
Anti-Infective Agents / administration & dosage*
Defecation / drug effects*
Digestive System Surgical Procedures / methods*
Double-Blind Method
Follow-Up Studies
Hemorrhoids / physiopathology,  surgery*
Metronidazole / administration & dosage*
Pain Measurement
Pain, Postoperative / drug therapy*,  physiopathology
Postoperative Care / methods
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Ointments; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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