Document Detail

Topical methimazole as a new treatment for postinflammatory hyperpigmentation: report of the first case.
MedLine Citation:
PMID:  16286748     Owner:  NLM     Status:  MEDLINE    
We have previously shown that the peroxidase inhibitor methimazole (1-methyl-2-mercapto imidazole; MMI) is a noncytotoxic inhibitor of melanin production in cultured B16 melanocytes. It was further demonstrated that the topical application of 5% MMI on brown guinea pig skin for 6 weeks causes a significant reduction in the amount of epidermal melanin, resulting in visually recognizable cutaneous depigmentation. Herein, we report a 27-year-old male with postinflammatory hyperpigmentation (due to acid burn), successfully treated with topical MMI as a new skin depigmenting agent. Topical 5% MMI caused a moderate to marked improvement of the hyperpigmented lesions within 6 weeks of once-daily application. Topical MMI was well tolerated by the patient and did not affect the level of serum thyroid hormones (free thyroxin, free triiodothyronine and the thyroid-stimulating hormone). Unlike most known depigmenting agents, such as hydroquinone and kojic acid, MMI is a noncytotoxic, nonmutagenic compound, and it is possible that MMI could serve as a novel agent for the treatment of hyperpigmentary disorders in human.
Behrooz Kasraee; Farhad Handjani; Amin Parhizgar; Gholamhosein R Omrani; Mohammad Reza Fallahi; Mitra Amini; Mohammad Nikbakhsh; Christian Tran; Ambros Hügin; Olivier Sorg; Jean-Hilaire Saurat
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  211     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2005  
Date Detail:
Created Date:  2005-11-15     Completed Date:  2006-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  360-2     Citation Subset:  IM    
Copyright Information:
Copyright 2005 S. Karger AG, Basel.
Jahrom School of Medical Sciences, Jahrom, Iran.
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MeSH Terms
Administration, Cutaneous
Burns, Chemical / complications
Dermatologic Agents / administration & dosage,  therapeutic use*
Facial Dermatoses / drug therapy*
Hyperpigmentation / drug therapy*
Melanins / antagonists & inhibitors*
Methimazole / administration & dosage,  therapeutic use*
Occupational Diseases / complications
Peroxidase / antagonists & inhibitors
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Dermatologic Agents; 0/Melanins; 60-56-0/Methimazole; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; EC

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