Document Detail


Topical lidocaine patch relieves postherpetic neuralgia more effectively than a vehicle topical patch: results of an enriched enrollment study.
MedLine Citation:
PMID:  10342414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study compared the efficacy of topical lidocaine patches versus vehicle (placebo) patches applied directly to the painful skin of subjects with postherpetic neuralgia (PHN) utilizing an 'enriched enrollment' study design. All subjects had been successfully treated with topical lidocaine patches on a regular basis for at least 1 month prior to study enrollment. Subjects were enrolled in a randomized, two-treatment period, vehicle-controlled, cross-over study. The primary efficacy variable was 'time to exit'; subjects were allowed to exit either treatment period if their pain relief score decreased by 2 or more categories on a 6-item Pain Relief Scale for any 2 consecutive days. The median time to exit with the lidocaine patch phase was greater than 14 days, whereas the vehicle patch exit time was 3.8 days (P < 0.001). At study completion, 25/32 (78.1%) of subjects preferred the lidocaine patch treatment phase as compared with 3/32 (9.4%) the placebo patch phase (P < 0.001). No statistical difference was noted between the active and placebo treatments with regards to side effects. Thus, topical lidocaine patch provides significantly more pain relief for PHN than does a vehicle patch. Topical lidocaine patch is a novel therapy for PHN that is effective, does not cause systemic side effects, and is simple to use.
Authors:
B S Galer; M C Rowbotham; J Perander; E Friedman
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pain     Volume:  80     ISSN:  0304-3959     ISO Abbreviation:  Pain     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-15     Completed Date:  1999-07-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7508686     Medline TA:  Pain     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
Affiliation:
Institute for Education and Research in Pain Medicine and Palliative Care, Department of Pain Medicine and Palliative Care, Beth Israel Medical Centre, New York, NY 10003, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Aged
Aged, 80 and over
Anesthetics, Local / administration & dosage*,  adverse effects
Cross-Over Studies
Double-Blind Method
Female
Herpes Zoster / complications*
Humans
Lidocaine / administration & dosage*,  adverse effects
Male
Middle Aged
Neuralgia / drug therapy*,  virology*
Pain Measurement
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 137-58-6/Lidocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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