Document Detail

Topical isotretinoin in Darier's disease.
MedLine Citation:
PMID:  8547046     Owner:  NLM     Status:  MEDLINE    
Topical 0.05% isotretinoin (Isotrex gel) was used to treat a test patch of skin in 11 patients with Darier's disease. Hyperkeratosis and papules improved in six patients after treatment for 3 months. Erythema, burning and irritation were common adverse effects, and these were severe in three patients, one of whom stopped treatment. Patients with mild Darier's disease may find topical isotretinoin helpful, but it is likely that most patients with widespread disease will require treatment with systemic retinoids.
S M Burge; P K Buxton
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  133     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-02-20     Completed Date:  1996-02-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  924-8     Citation Subset:  IM    
Department of Dermatology, Stoke Mandeville Hospital NHS Trust, Aylesbury, Bucks, UK.
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MeSH Terms
Administration, Cutaneous
Darier Disease / drug therapy*
Drug Administration Schedule
Isotretinoin / administration & dosage*
Keratolytic Agents / administration & dosage*
Middle Aged
Reg. No./Substance:
0/Keratolytic Agents; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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