| Topical isoflavones provide effective photoprotection to skin. | |
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MedLine Citation:
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PMID: 18353084 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/PURPOSE: Isoflavones, one main group of phytoestrogens, have antioxidative and photoprotective effects in cellular and mouse studies. The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model. METHODS: The pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C and 1% vitamin E and 0.5% ferulic acid (CEF) daily for 4 days. Skin was irradiated with solar-simulated UV irradiation, 1 to 5 minimal erythema dose (MED) at 1-MED intervals. Evaluation was carried out 24 h later by colorimeter-measured erythema and sunburn cell numbers. RESULTS: Topical application of 0.5% solutions of three individual phytoestrogens - genistein, daidzein, biochanin A - are better than similar solutions of equol or formononetin in protecting pig skin from solar-simulated ultraviolet (SSUV)-induced photodamage, as measured by sunburn cell formation and/or erythema. However, the protection was less than that provided by a topical combination antioxidant standard containing 15% L-ascorbic acid, 1%alpha-tocopherol, and 0.5% ferulic acid. CONCLUSION: Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage. |
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Authors:
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Jing-Yi Lin; Joshua A Tournas; James A Burch; Nancy A Monteiro-Riviere; Jan Zielinski |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 24 ISSN: 1600-0781 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-20 Completed Date: 2008-04-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
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Languages: eng Pagination: 61-6 Citation Subset: IM |
Affiliation:
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Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan. lindajylin@adm.cgmh.org.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Ascorbic Acid / administration & dosage, pharmacology, therapeutic use Coumaric Acids / administration & dosage, pharmacology, therapeutic use Dose-Response Relationship, Drug Drug Combinations Genistein / administration & dosage, pharmacology, therapeutic use Isoflavones / administration & dosage, pharmacology*, therapeutic use Phytotherapy* Plants, Medicinal* Skin / drug effects*, radiation effects Sunburn / pathology, prevention & control* Sunlight / adverse effects Sunscreening Agents / administration & dosage, pharmacology*, therapeutic use Swine Vitamin E / administration & dosage, pharmacology, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Coumaric Acids; 0/Drug Combinations; 0/Isoflavones; 0/Sunscreening Agents; 1135-24-6/ferulic acid; 1406-18-4/Vitamin E; 446-72-0/Genistein; 485-72-3/formononetin; 486-66-8/daidzein; 491-80-5/biochanin A; 50-81-7/Ascorbic Acid; 531-95-3/equol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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