Document Detail

Topical isoflavones provide effective photoprotection to skin.
MedLine Citation:
PMID:  18353084     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/PURPOSE: Isoflavones, one main group of phytoestrogens, have antioxidative and photoprotective effects in cellular and mouse studies. The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model. METHODS: The pig skin was treated with five well-known isoflavone compounds (genistein, equol, daidzein, biochanin A, and formononetin) and one antioxidant combination solution of 15% vitamin C and 1% vitamin E and 0.5% ferulic acid (CEF) daily for 4 days. Skin was irradiated with solar-simulated UV irradiation, 1 to 5 minimal erythema dose (MED) at 1-MED intervals. Evaluation was carried out 24 h later by colorimeter-measured erythema and sunburn cell numbers. RESULTS: Topical application of 0.5% solutions of three individual phytoestrogens - genistein, daidzein, biochanin A - are better than similar solutions of equol or formononetin in protecting pig skin from solar-simulated ultraviolet (SSUV)-induced photodamage, as measured by sunburn cell formation and/or erythema. However, the protection was less than that provided by a topical combination antioxidant standard containing 15% L-ascorbic acid, 1%alpha-tocopherol, and 0.5% ferulic acid. CONCLUSION: Isoflavones provide effective photoprotection and are good candidate ingredients for protection against ultraviolet (UV) photodamage.
Jing-Yi Lin; Joshua A Tournas; James A Burch; Nancy A Monteiro-Riviere; Jan Zielinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  61-6     Citation Subset:  IM    
Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.
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MeSH Terms
Administration, Cutaneous
Ascorbic Acid / administration & dosage,  pharmacology,  therapeutic use
Coumaric Acids / administration & dosage,  pharmacology,  therapeutic use
Dose-Response Relationship, Drug
Drug Combinations
Genistein / administration & dosage,  pharmacology,  therapeutic use
Isoflavones / administration & dosage,  pharmacology*,  therapeutic use
Plants, Medicinal*
Skin / drug effects*,  radiation effects
Sunburn / pathology,  prevention & control*
Sunlight / adverse effects
Sunscreening Agents / administration & dosage,  pharmacology*,  therapeutic use
Vitamin E / administration & dosage,  pharmacology,  therapeutic use
Reg. No./Substance:
0/Coumaric Acids; 0/Drug Combinations; 0/Isoflavones; 0/Sunscreening Agents; 1135-24-6/ferulic acid; 1406-18-4/Vitamin E; 446-72-0/Genistein; 485-72-3/formononetin; 486-66-8/daidzein; 491-80-5/biochanin A; 50-81-7/Ascorbic Acid; 531-95-3/equol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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