| Topical iodine-containing antiseptics and neonatal hypothyroidism in very-low-birthweight infants. | |
| | |
MedLine Citation:
|
PMID: 2570908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The thyroid function of very-low-birthweight (VLBW; below 1500 g) infants admitted to neonatal intensive-care units was studied at two hospitals; one routinely used topical iodinated antiseptic agents and the other used chlorhexidine-containing antiseptics. Serial monitoring of urinary iodine excretion and serum thyrotropin and thyroxine levels was undertaken from birth for the first 4 weeks of life. Urinary iodine excretion rose dramatically in the 54 iodine-exposed infants and was up to fifty times greater than in the 29 non-exposed infants. Within 14 days, 25% (9 of 36) of the infants exposed to iodine had serum thyrotropin levels above 20 mIU/l, compared with none of the control group. The mean serum thyroxine level in these 9 infants (44.1 nmol/l) was significantly lower than that in exposed infants with normal thyrotropin levels (83.1 nmol/l) and in the non-exposed control group (83.0 nmol/l); thyroxine levels fell before serum thyrotropin rose. These disturbances in thyroid function correlated positively with urinary iodine excretion and hence iodine absorption. Thyroid function had returned to normal by the time of discharge from hospital. It is concluded that iodine absorption, from topical iodine-containing antiseptics, may cause hypothyroidism during a critical period of neurological development in the newborn infant. The routine use of iodine antisepsis in VLBW infants should be avoided because of this effect. |
| | |
Authors:
|
P Smerdely; A Lim; S C Boyages; K Waite; D Wu; V Roberts; G Leslie; J Arnold; E John; C J Eastman |
Related Documents
:
|
11592578 - Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to grave... 7190978 - Changes in the circulating form of serum somatomedin-c during fetal life. 22435968 - Effect of endotoxin and allergens on neonatal lung function and infancy respiratory sym... 15167738 - Primary congenital upper eyelid retraction in infants and children. 11592578 - Neonatal hyperthyroidism in infants of mothers previously thyroidectomized due to grave... 9754518 - Diagnosing delirium by telephone. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Lancet Volume: 2 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 1989 Sep |
Date Detail:
|
Created Date: 1989-10-18 Completed Date: 1989-10-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 2985213R Medline TA: Lancet Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 661-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Medicine, Westmead Hospital, Sydney, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Anti-Infective Agents, Local / administration & dosage, adverse effects*, pharmacokinetics, urine Humans Hypothyroidism / chemically induced*, metabolism Infant, Low Birth Weight* Infant, Newborn Intensive Care Units, Neonatal Iodine / administration & dosage, adverse effects*, pharmacokinetics, urine Prospective Studies Thyrotropin / blood Thyroxine / blood |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Infective Agents, Local; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particle...
Next Document: Radiotherapy for Paget's disease of the nipple: a conservative alternative.