Document Detail

Topical interferon alpha 2 beta therapy in the management of conjunctival papilloma.
MedLine Citation:
PMID:  17400137     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This article describes the differential diagnosis of conjunctival papillomas and reviews the treatment options with a focus on the new topical interferon alpha 2 beta therapy. CASE: A 45-year-old white man presented with a red right eye of approximately 6 months' duration. The lesion was suspicious and suggestive of malignancy; therefore, the patient was referred for consultation. The lesion was diagnosed as a conjunctival papilloma. The patient was placed on topical interferon alpha 2 beta eye drops, and within 2 weeks he experienced complete lesion regression. CONCLUSION: Interferons, in particular interferon alpha-2b (IFN-alpha2beta), have recently been shown to be successful in treating conjunctival papillomas and conjunctival intraepithelial neoplasia (CIN). Previously, treatment was limited to observation for asymptomatic patients. Larger lesions in symptomatic patients were treated by surgical excision and cryotherapy. Additional treatment modalities included topical antimetabolite treatment with mitomycin-C and 5-fluorouracil. These treatments, although effective, had significant attendant postsurgical complications and toxic ocular adverse reactions. Interferons represent a new successful treatment modality.
Laura A Falco; Paul J Gruosso; Keith Skolnick; Lorena Bejar
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Optometry (St. Louis, Mo.)     Volume:  78     ISSN:  1529-1839     ISO Abbreviation:  Optometry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-05-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100912421     Medline TA:  Optometry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  162-6     Citation Subset:  IM    
College of Optometry, Nova Southeastern University, Fort Lauderdale, Florida 33328, USA.
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MeSH Terms
Antineoplastic Agents / administration & dosage*,  therapeutic use
Conjunctival Neoplasms / drug therapy*,  pathology
Follow-Up Studies
Interferon Alfa-2b / administration & dosage*,  therapeutic use
Middle Aged
Ophthalmic Solutions
Papilloma / drug therapy*,  pathology
Reg. No./Substance:
0/Antineoplastic Agents; 0/Ophthalmic Solutions; 99210-65-8/Interferon Alfa-2b

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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