Document Detail

Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma.
MedLine Citation:
PMID:  10505155     Owner:  NLM     Status:  MEDLINE    
Intubation granuloma of the larynx is an iatrogenic disease which is induced by endotracheal intubation. It has basically been managed by conservative medical treatment with observation. Surgical excision can be considered as a last resort due to the high recurrence rate which subjects the patients to repeated anaesthesia. The purpose of this study is to evaluate the therapeutic effect of topical steroid in intubation granuloma, comparing the results of conservative medical treatment with, or without, surgery (Group I, 14 patients) and inhalant therapy with topical budesonide (Group II, 20 patients). In Group I, complete disappearance of granuloma occurred in six cases within a year (42.8 per cent) with conservative therapy only. Microlaryngeal surgery was performed on the eight cases of persisting granuloma after conservative therapy for a year, resulting in two cases of recurrence. In Group II, the granuloma disappeared completely in 85 per cent within six months and in 95 per cent within 12 months without any remarkable side-effects. We concluded that intubation granuloma of the larynx could be treated with topical inhalant steroid as the first choice of therapy rather than other medical treatment or surgical intervention.
H J Roh; E K Goh; K M Chon; S G Wang
Related Documents :
1182385 - Class change in the personal illness hierarchy.
2317675 - Role of intraoperative prograde colonic lavage and a decompressive loop ileostomy in th...
12540305 - Korean red ginseng effective for treatment of erectile dysfunction.
12296905 - Effect on outcome of early intensive management of geriatric trauma patients.
23828875 - Chads2 and cha2ds2-vasc scores to predict morbidity and mortality in heart failure pati...
18387695 - Impact of preoperative screening for meticillin-resistant staphylococcus aureus by real...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  113     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  AIM; IM    
Department of Otolaryngology, College of Medicine, Pusan National University, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Administration, Topical
Anti-Inflammatory Agents / therapeutic use*
Budesonide / therapeutic use*
Follow-Up Studies
Granuloma, Laryngeal / drug therapy*,  etiology,  surgery
Intubation, Intratracheal / adverse effects*
Middle Aged
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 51333-22-3/Budesonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Presentation and epidemiology of nasopharyngeal carcinoma in Jordan.
Next Document:  Laryngeal preservation by treatment with induction chemotherapy and radiotherapy protocol for stage ...