Document Detail


Topical inhalant steroid (budesonide, Pulmicort nasal) therapy in intubation granuloma.
MedLine Citation:
PMID:  10505155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intubation granuloma of the larynx is an iatrogenic disease which is induced by endotracheal intubation. It has basically been managed by conservative medical treatment with observation. Surgical excision can be considered as a last resort due to the high recurrence rate which subjects the patients to repeated anaesthesia. The purpose of this study is to evaluate the therapeutic effect of topical steroid in intubation granuloma, comparing the results of conservative medical treatment with, or without, surgery (Group I, 14 patients) and inhalant therapy with topical budesonide (Group II, 20 patients). In Group I, complete disappearance of granuloma occurred in six cases within a year (42.8 per cent) with conservative therapy only. Microlaryngeal surgery was performed on the eight cases of persisting granuloma after conservative therapy for a year, resulting in two cases of recurrence. In Group II, the granuloma disappeared completely in 85 per cent within six months and in 95 per cent within 12 months without any remarkable side-effects. We concluded that intubation granuloma of the larynx could be treated with topical inhalant steroid as the first choice of therapy rather than other medical treatment or surgical intervention.
Authors:
H J Roh; E K Goh; K M Chon; S G Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  113     ISSN:  0022-2151     ISO Abbreviation:  J Laryngol Otol     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  AIM; IM    
Affiliation:
Department of Otolaryngology, College of Medicine, Pusan National University, Korea.
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Administration, Topical
Adult
Anti-Inflammatory Agents / therapeutic use*
Budesonide / therapeutic use*
Female
Follow-Up Studies
Glucocorticoids
Granuloma, Laryngeal / drug therapy*,  etiology,  surgery
Humans
Intubation, Intratracheal / adverse effects*
Laryngoscopy
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 51333-22-3/Budesonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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