| Topical ibopamine in the treatment of chronic ocular hypotony attributable to vitreoretinal surgery, uveitis, or penetrating trauma. | |
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MedLine Citation:
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PMID: 16490513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study whether topical ibopamine effectively increases the intraocular pressure in patients with ocular hypotony after vitreoretinal surgery, uveitis, or penetrating trauma. DESIGN: A prospective randomized, double-blind, placebo controlled, crossover study. METHODS: In ten patients with ocular hypotony, an ibopamine 2% solution or placebo eyedrop was administered at 8 am and frequent applanation tonometry was performed during 10 hours on 2 days, 2 weeks apart. RESULTS: The mean IOP integral after administration of ibopamine was 2.4 mm Hg higher (95% CI for median difference in AUC over 480 minutes [P = .010]) compared with placebo. CONCLUSIONS: The results of the study show that an ibopamine 2% eyedrop twice a day may increase the IOP for a period of over 8 hours in patients with hypotony. |
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Authors:
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Luana Cahya Ugahary; Elisabeth Ganteris; Marc Veckeneer; Adam C Cohen; Jan Jansen; Paul G H Mulder; Jan C van Meurs |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of ophthalmology Volume: 141 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-21 Completed Date: 2006-03-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 571-3 Citation Subset: AIM; IM |
Affiliation:
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The Rotterdam Eye Hospital, PO Box 70030, 3000 LM Rotterdam, The Netherlands. Ugahary@oogziekenhuis.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Chronic Disease Cross-Over Studies Deoxyepinephrine / administration & dosage, analogs & derivatives*, therapeutic use Dopamine Agonists / administration & dosage, therapeutic use* Double-Blind Method Eye Injuries, Penetrating / complications* Female Humans Intraocular Pressure / drug effects* Male Middle Aged Ocular Hypotension / drug therapy*, etiology Prospective Studies Tonometry, Ocular Uveitis / complications* Visual Acuity Vitrectomy / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 501-15-5/Deoxyepinephrine; 66195-31-1/ibopamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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