| Topical endotracheal mitomycin C as a complementary treatment for endoscopic treatment of recurrent laryngotracheal stenosis. | |
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MedLine Citation:
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PMID: 20663704 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the preparation of topical endotracheal mitomycin C and the clinical outcomes of four patients with recurrent and severe laryngotracheal stenosis (LTS) treated with adjuvant topical mitomycin C. METHOD: Literature review to determine the concentration and method of preparation of topical mitomycin C for endotracheal use. Review of clinical histories. RESULTS: We established a concentration of 0.4 mg/ml topical mitomycin C for the treatment of laryngotracheal stenosis. In the treated cases, we applied a 0.4 mg/ml solution to the wound site following laser surgery and dilatation with bronchoscope. Three patients remain asymptomatic from a respiratory perspective, and treatment failed in one case. CONCLUSIONS: LTS treatment is complex due to the continuous development of granulation tissue and fibrosis following injury to the airways. Topical mitomycin C seems to be the ideal adjuvant agent thanks to its powerful antifibrotic effects. |
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Authors:
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S Cortés de Miguel; J Cabeza Barrera; M Gallardo Medina; L F Cassini Gómez de Cádiz; A Salmerón-García; F Rodríguez Lucas |
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Publication Detail:
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Type: Journal Article Date: 2010-12-16 |
Journal Detail:
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Title: Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria Volume: 35 ISSN: 1130-6343 ISO Abbreviation: Farm Hosp Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440679 Medline TA: Farm Hosp Country: Spain |
Other Details:
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Languages: eng; spa Pagination: 32-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 SEFH. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Farmacia, Hospital Universitario San Cecilio, Granada, España. soldelsur@libero.it |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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