Document Detail

Topical effects of frog "Rana ridibunda" skin secretions on wound healing and reduction of wound microbial load.
MedLine Citation:
PMID:  23261484     Owner:  NLM     Status:  Publisher    
ETHNOPHARMACOLOGICAL RELEVANCE: Study of the interrelationships between human and the animals in their environment always has been subject of interest and caused discoveries of the animal applications in medicine. From the latest century, these remedies called back in traditional medicine of Vietnam and South America and frog skin was used as a biological dressing and had good effects in healing wounds. Also, frog skin secretions have wound healing properties and reduce inflammation. In this study we applied these secretions in from of ointment to investigate their healing activities. MATERIALS AND METHODS: Skin secretions were extracted from Rana ridibunda to evaluate their effects on wound healing in mice. Secretion used as raw extract (RE) and ultrafiltrated extract, using a membrane with cutoff 10kDa as Under 10kDa (U10E), and administrated as ointment every 48hours on wound site. Control group was left without any treatment and also there was other group treated with ointment (O group) alone. On 2, 4 and 6 days post-injury, animals were euthanized and images were taken for wound closure evaluation. Then wound locations were removed for histological assays. Also wound microbial load have examined. Observational parameters including wound closure, and wound microbiology in experimental groups compared with the control and O groups have been done. RESULTS: The results showed U10E group has better effects than RE, O and control groups. Histological parameters, including numbers of inflammatory and fibroblast cells and amount of collagen fibers, neovascularization, as well, represented greater degree of wound healing in U10E group compared with RE, O, and control groups. CONCLUSIONS: Our results showed that frog skin secretions were significantly effective in promoting wound healing process. The U10E extract from frog R. ridibunda possess a potent accelerating wound healing effect that promise good potentials for clinical application in the wound care. Further studies will be required to characterize special molecules encompassing healing properties.
Mohammad Mashreghi; Mahere Rezazade Bazaz; Nasser Mahdavi Shahri; Ahmad Asoodeh; Mansour Mashreghi; Morteza Behnam Rassouli; Shiva Golmohammadzadeh
Related Documents :
17707784 - Preparation of laser micropore porcine acellular dermal matrix for skin graft: an exper...
18091504 - Pedicled omental flaps as an adjunct in the closure of complex spinal wounds.
24008654 - Influence of carotid injury in post-myocardial revascularization surgery and its late e...
23951824 - Factors influencing the outcome of decompressive craniectomy used in the treatment of s...
23732464 - Improving quality of care in peptic ulcer bleeding: nationwide cohort study of 13,498 c...
25022224 - A multicentre, comparative study of cera septal occluder versus amplatzer septal occlud...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-19
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  -     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A herbal formula containing roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhib...
Next Document:  Icariin from Epimedium brevicornum Maxim promotes the biosynthesis of estrogen by aromatase (CYP19).