Document Detail

Topical diclofenac sodium for treatment of postoperative inflammation in cataract surgery.
MedLine Citation:
PMID:  11217255     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the effect of a topical non-steroidal anti-inflammatory drug as an alternative to topical steroids for postoperative control of inflammation in cataract surgery. METHODS: The effect of diclofenac sodium 0.1% following cataract surgery was studied and compared to routine corticosteroid, dexamethasone phosphate 1% in a prospective, double-blind randomized study. Both groups were similar in baseline parameters. Postoperative inflammatory response, intraocular pressure and best-corrected visual acuity following standard extracapsular cataract extraction were assessed in both groups in the initial 21 days and the severity of these parameters was graded. The severity of postoperative inflammatory response to the two drugs was graded at 1, 3, 7, 14 and 21 days. Intraocular pressure and visual acuity at baseline and endpoint were compared and statistically analyzed. RESULTS: The two groups did not differ statistically in treatment effect for any of the variables including aqueous cells, flare, ciliary congestion, Descemet's folds, visual acuity and intraocular pressure (p < 0.001). However there seemed to be a trend towards quicker improvement with corticosteroid when cells in the anterior chamber were considered. There were no side effects from topical diclofenac, and it was well tolerated. CONCLUSION: Diclofenac sodium is as effective as topical corticosteroid and can be used as an alternative in routine postoperative treatment following uncomplicated cataract surgery.
M S Reddy; N Suneetha; R K Thomas; R R Battu
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Indian journal of ophthalmology     Volume:  48     ISSN:  0301-4738     ISO Abbreviation:  Indian J Ophthalmol     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2001-02-19     Completed Date:  2001-03-15     Revised Date:  2008-09-03    
Medline Journal Info:
Nlm Unique ID:  0405376     Medline TA:  Indian J Ophthalmol     Country:  India    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Dept. of Ophthalmology, St. John's Medical College and Hospital, Sarjapur Road, Bangalore-560 034, India.
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MeSH Terms
Anterior Chamber / pathology
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Cataract Extraction / adverse effects*
Cell Count
Dexamethasone / administration & dosage,  analogs & derivatives*
Diclofenac / administration & dosage*
Double-Blind Method
Endophthalmitis / drug therapy*,  etiology
Middle Aged
Ophthalmic Solutions
Prospective Studies
Severity of Illness Index
Visual Acuity
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 312-93-6/dexamethasone 21-phosphate; 50-02-2/Dexamethasone

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