Document Detail

Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: a new method in hypertrophic scar treatment.
MedLine Citation:
PMID:  23414164     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Epidermal permeability alterations induced by ablative fractional resurfacing and low-frequency ultrasound technology may offer drug delivery for the treatment of hypertrophic scars through transepidermal drug delivery (TED). This technology can improve treatment efficacy and minimize side effects.
OBJECTIVE: To evaluate clinical response and side effects of TED technology in hypertrophic scars in the body and on the face using ablative fractional radiofrequency (RF) associated with low-frequency acoustic pressure ultrasound (US).
METHODS: Four patients with hypertrophic scars were treated with triamcinolone using fractional ablative RF and US. The treatment procedure comprised three steps: (i) ablative fractional RF for skin perforation; (ii) topical application of triamcinolone acetonide 20 mg/ml on the perforated skin; and (iii) acoustic pressure wave US applied to enhance triamcinolone penetration into the skin.
RESULTS: Complete resolution was seen after one session in patients with scars on the nose and mandibular area. The scar on the neck showed complete resolution after four sessions. The scar on the knee showed a marked improvement after four sessions. Mild and homogeneous atrophy was observed in hypertrophic scars on the neck.
CONCLUSION: Ablative fractional RF associated with acoustic pressure US is a new technology aiming to increase drug delivery into skin. This new method can improve the efficacy of steroids in hypertrophic scar treatment, minimizing the risks of localized atrophy and irregular appearance of the treated lesion.
Maria C A Issa; Luiza E B P Kassuga; Natalia S Chevrand; Marianna T F Pires
Related Documents :
12400924 - Exposure to anti-cancer drugs during preparation and administration. investigations of ...
24607204 - Cell viability of fibroblasts to pifenidone and sirolimus: a future concept for drug el...
23337524 - Call to action: finding solutions for the drug shortage crisis in the united states.
23687924 - Therapeutic proteins and nanotechnology: immune response and stealth bioengineered cons...
24946254 - Exploring inflammatory disease drug effects on neutrophil function.
9183864 - Biomedical applications of nanotechnology--implications for drug targeting and gene the...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  52     ISSN:  1365-4632     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  IM    
Copyright Information:
© 2013 The International Society of Dermatology.
Department of Dermatology, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of isotretinoin on serum vitamin E levels in patients with acne.
Next Document:  Synthesis and properties of Fe3O4-activated carbon magnetic nanoparticles for removal of aniline fro...