Document Detail

Topical cyclosporine as a possible new antimetabolite in trabeculectomy.
MedLine Citation:
PMID:  8782257     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: The authors conducted a randomized, prospective, and controlled clinical and transmission electron microscopic study to investigate the possible role of cyclosporine in trabeculectomy as an antimetabolite agent. PATIENTS AND METHODS: Twelve patients underwent trabeculectomy with topical cyclosporine and another 12 patients had trabeculectomy without cyclosporine. RESULTS: There was a statistically significant decrease in the postoperative intraocular pressure (P < .05) and in the number of medications needed postoperatively (P < .01) in the cyclosporine group. There were no significant complications in either group. Transmission electron microscopic examinations of the excised trabecular scleral tissue showed that cyclosporine caused inhibition of fibroblasts and led to a disruption in collagen organization at the level of the surgical dissection. Middle scleral layers were generally not affected except in some cyclosporine-treated eyes, which showed only a mild cytopathic effect. CONCLUSION: This study showed that topical cyclosporine was safe and effective for use as an antimetabolite in trabeculectomy. Further studies are needed to substantiate the adjuvant role of cyclosporine in glaucoma filtering operations.
M E Turaçli; K Gündüz; G Aktan; H Sencer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Ophthalmic surgery and lasers     Volume:  27     ISSN:  1082-3069     ISO Abbreviation:  Ophthalmic Surg Lasers     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-11-04     Completed Date:  1996-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9517132     Medline TA:  Ophthalmic Surg Lasers     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  438-44     Citation Subset:  IM    
Department of Ophthalmology, Faculty of Medicine, University of Ankara, Turkey.
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MeSH Terms
Administration, Topical
Antimetabolites / administration & dosage*
Cyclosporine / administration & dosage*
Data Interpretation, Statistical
Follow-Up Studies
Glaucoma, Open-Angle / pathology,  physiopathology,  surgery*
Immunosuppressive Agents / administration & dosage*
Intraocular Pressure
Middle Aged
Ophthalmic Solutions
Postoperative Complications / prevention & control*
Prospective Studies
Trabecular Meshwork / ultrastructure
Trabeculectomy / methods*
Reg. No./Substance:
0/Antimetabolites; 0/Immunosuppressive Agents; 0/Ophthalmic Solutions; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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