| Topical clobetasol propionate compared with placebo in the treatment of unretractable foreskin. | |
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MedLine Citation:
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PMID: 9001879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess whether it is the steroid alone or the gentle physical retraction combined with ointment that is responsible for the excellent results observed with topical steroid treatment of unretractable foreskin. DESIGN: Prospective, randomised, double-blind study. SETTING: University hospital, Sweden. SUBJECTS: 30 Boys randomised to be treated with clobetasol propionate (n = 15) or placebo (n = 15). INTERVENTIONS: The boys were examined 1, 2 and 6 months, respectively, after treatment. MAIN OUTCOME MEASURES: Comparison between the effects of clobetasol propionate and placebo. RESULTS: Two patients in the steroid group and one in the placebo group withdrew from the study. 10 Boys in the steroid group showed an improvement within 2 months. The remaining 3 boys had no effect and were circumcised. Histopathological examination showed lichen sclerosus et atrophicus. Seven boys in the placebo group improved. The 7 non-responders were prescribed clobetasol propionate ointment, and all 7 improved. CONCLUSION: 17 of 27 boys referred with "phimosis" were successfully treated with an ointment and gentle traction. When clobetasol propionate was given the non-responders success rate was increased to 24/27 (89%). |
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Authors:
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T Lindhagen |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The European journal of surgery = Acta chirurgica Volume: 162 ISSN: 1102-4151 ISO Abbreviation: Eur J Surg Publication Date: 1996 Dec |
Date Detail:
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Created Date: 1997-03-18 Completed Date: 1997-03-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105264 Medline TA: Eur J Surg Country: NORWAY |
Other Details:
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Languages: eng Pagination: 969-72 Citation Subset: IM |
Affiliation:
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Dept of Surgery, University Hospital MAS, Malmö, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Anti-Inflammatory Agents / therapeutic use* Child Child, Preschool Circumcision, Male Clobetasol / analogs & derivatives*, therapeutic use Diagnosis, Differential Double-Blind Method Glucocorticoids Humans Lichen Sclerosus et Atrophicus / complications, diagnosis Male Penile Diseases / complications, diagnosis Phimosis / drug therapy*, etiology, surgery Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Glucocorticoids; 25122-41-2/Clobetasol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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