Document Detail

Topical clobetasol propionate compared with placebo in the treatment of unretractable foreskin.
MedLine Citation:
PMID:  9001879     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess whether it is the steroid alone or the gentle physical retraction combined with ointment that is responsible for the excellent results observed with topical steroid treatment of unretractable foreskin. DESIGN: Prospective, randomised, double-blind study. SETTING: University hospital, Sweden. SUBJECTS: 30 Boys randomised to be treated with clobetasol propionate (n = 15) or placebo (n = 15). INTERVENTIONS: The boys were examined 1, 2 and 6 months, respectively, after treatment. MAIN OUTCOME MEASURES: Comparison between the effects of clobetasol propionate and placebo. RESULTS: Two patients in the steroid group and one in the placebo group withdrew from the study. 10 Boys in the steroid group showed an improvement within 2 months. The remaining 3 boys had no effect and were circumcised. Histopathological examination showed lichen sclerosus et atrophicus. Seven boys in the placebo group improved. The 7 non-responders were prescribed clobetasol propionate ointment, and all 7 improved. CONCLUSION: 17 of 27 boys referred with "phimosis" were successfully treated with an ointment and gentle traction. When clobetasol propionate was given the non-responders success rate was increased to 24/27 (89%).
T Lindhagen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European journal of surgery = Acta chirurgica     Volume:  162     ISSN:  1102-4151     ISO Abbreviation:  Eur J Surg     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-03-18     Completed Date:  1997-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105264     Medline TA:  Eur J Surg     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  969-72     Citation Subset:  IM    
Dept of Surgery, University Hospital MAS, Malmö, Sweden.
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / therapeutic use*
Child, Preschool
Circumcision, Male
Clobetasol / analogs & derivatives*,  therapeutic use
Diagnosis, Differential
Double-Blind Method
Lichen Sclerosus et Atrophicus / complications,  diagnosis
Penile Diseases / complications,  diagnosis
Phimosis / drug therapy*,  etiology,  surgery
Prospective Studies
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 25122-41-2/Clobetasol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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