Document Detail

Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice.
MedLine Citation:
PMID:  8578946     Owner:  NLM     Status:  MEDLINE    
Cis-urocanic acid, converted from trans-urocanic acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-urocanic acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-urocanic acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-urocanic acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-urocanic acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-urocanic acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate.
A I Lauerma; A Aioi; H I Maibach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  75     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-03-14     Completed Date:  1996-03-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  272-5     Citation Subset:  IM    
Department of Dermatology, University of California, San Francisco 94143-0989, USA.
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MeSH Terms
Administration, Topical
Croton Oil
Dermatitis, Contact / etiology,  physiopathology*
Mice, Inbred BALB C
Phthalic Anhydrides
Urocanic Acid / administration & dosage*
Reg. No./Substance:
0/Allergens; 0/Irritants; 0/Phthalic Anhydrides; 104-98-3/Urocanic Acid; 15646-46-5/Oxazolone; 552-30-7/trimellitic anhydride; 8001-28-3/Croton Oil

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