| Topical cis-urocanic acid suppresses both induction and elicitation of contact hypersensitivity in BALB/C mice. | |
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MedLine Citation:
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PMID: 8578946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cis-urocanic acid, converted from trans-urocanic acid in stratum corneum by ultraviolet B irradiation, has been shown to impair contact hypersensitivity induction. To study whether topical cis-urocanic acid also alters contact hypersensitivity elicitation, as well as immediate hypersensitivity and acute irritation, we treated mice with 1% topical cis-urocanic acid or vehicle prior to induction or elicitation of hypersensitivity to contact allergen oxazolone or respiratory allergen trimellitic anhydride or prior to acute irritation from croton oil. Topical cis-urocanic acid suppressed both induction and elicitation of contact hypersensitivity to oxazolone. However, no effect by cis-urocanic acid on induction or elicitation of trimellitic anhydride allergy or croton oil irritation was seen. The possible efficacy of topical cis-urocanic acid as a treatment of inflammatory skin diseases responsive to ultraviolet B irradiation may be worthwhile to investigate. |
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Authors:
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A I Lauerma; A Aioi; H I Maibach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 75 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1996-03-14 Completed Date: 1996-03-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 272-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of California, San Francisco 94143-0989, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Allergens Animals Croton Oil Dermatitis, Contact / etiology, physiopathology* Female Irritants Mice Mice, Inbred BALB C Oxazolone Phthalic Anhydrides Urocanic Acid / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Irritants; 0/Phthalic Anhydrides; 104-98-3/Urocanic Acid; 15646-46-5/Oxazolone; 552-30-7/trimellitic anhydride; 8001-28-3/Croton Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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