Document Detail

Topical ciprofloxacin versus topical gentamicin for chronic otitis media.
MedLine Citation:
PMID:  12596948     Owner:  NLM     Status:  MEDLINE    
We compared the therapeutic efficiency of ciprofloxacin hydrochloride and gentamicin sulfate in the treatment of chronic otitis media. A total of 88 patients aged 9-62 years with chronic suppurative media were randomly placed into two groups. In the first group, 48 patients (54.5%) received topical ciprofloxacin hydrochloride, while in the second group 40 patients (45.5%) received local gentamicin sulfate. Of the 48 patients who received ciprofloxacin hydrochloride, 42 (87.5%) were cured, while in 6 patients (12.5%) the treatment failed. In the gentamicin group, 12 (30%) of the patients were cured, while 28 patients showed no clinical or bacteriological improvement. Topical ciprofloxacin is safe and more efficacious and efficient than topical gentamicin in the treatment of acute exacerbation of chronic suppurative otitis media.
O Nawasreh; A Fraihat
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  7     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:    2001 Jan-Mar
Date Detail:
Created Date:  2003-02-24     Completed Date:  2003-03-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Prince Rashid Ben Al-Hasan Hospital, Al-Husn, Jordan.
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MeSH Terms
Administration, Topical
Anti-Bacterial Agents / therapeutic use*
Anti-Infective Agents / therapeutic use*
Bacterial Infections / complications*
Chronic Disease
Ciprofloxacin / therapeutic use*
Drug Resistance, Microbial
Gentamicins / therapeutic use*
Instillation, Drug
Microbial Sensitivity Tests
Middle Aged
Otitis Media, Suppurative / drug therapy*,  microbiology*
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Gentamicins; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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