| Topical application of isosorbide dinitrate in patients with persistent constipation after pull-through surgery for Hirschsprung's disease. | |
| | |
MedLine Citation:
|
PMID: 17407025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: The aim of this study was to evaluate the anal manometric changes and the clinical effects after topical application of isosorbide dinitrate (ISDN) in patients with persistent constipation after pull-through surgery for Hirschsprung's disease (HD). METHODS: We studied 3 children (2 males and 1 female), aged 2, 3 and 5 years respectively, who had undergone the Soave-Boley surgical procedure for HD and who suffered from persistent constipation after operation. We performed a pre- and postoperative anorectal manometry study and we applied ISDN paste (1 mg/kg two times daily) in the anal region for three weeks. All patients were followed-up and re-evaluated at 1, 3, and 6 months. RESULTS: All patients showed an improvement of symptoms, with an average of 4 spontaneous evacuations per week. Prior to the topical treatment, the medium pressure was 115.6 mmHg (range 102 - 130 mmHg), the maximum pressure was 160 mmHg (range 145 - 175 mmHg), and the medium length of the high pressure zone was 1.8 cm (range 1.5 - 2.0 cm). At the 6 month follow-up, the medium pressure was 57.3 mmHg (range 52 - 61 mmHg, a decrease of 54.4 %), the maximum pressure was 98 mmHg (range 88 - 107 mmHg; a decrease of 38.7 %), and the medium length of the high pressure zone was 1.6 cm (range 1.4 - 1.8 cm; a decrease of 11.1 %). CONCLUSIONS: Topical treatment with ISDN is a valid therapeutic alternative to an anal myotomy in patients with persistent constipation after pull-through surgery for HD. However, a greater number of cases and a longer follow-up are necessary to confirm the validity of our experience. |
| | |
Authors:
|
M Messina; G Amato; D Meucci; F Molinaro; N Nardi |
Related Documents
:
|
16839965 - Gastric pressure response to low dose dopamine infusion in normal man. 16086705 - Mechanoreceptors of the proximal stomach and perception of gastric distension. 9223025 - Endogenous nitric oxide in the control of esophageal motility in humans. 15306575 - Relationship between motor function of the proximal stomach and transient lower oesopha... 703935 - Servo-controlled lumbar infusions: a clinical tool for the determination of csf dynamic... 15851645 - Elevated blood pressure and risk of end-stage renal disease in subjects without baselin... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift für Kinderchirurgie Volume: 17 ISSN: 0939-7248 ISO Abbreviation: Eur J Pediatr Surg Publication Date: 2007 Feb |
Date Detail:
|
Created Date: 2007-04-04 Completed Date: 2007-09-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105263 Medline TA: Eur J Pediatr Surg Country: Germany |
Other Details:
|
Languages: eng Pagination: 62-5 Citation Subset: IM |
Affiliation:
|
Section of Pediatric Surgery, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy. messinam@unisi.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Anal Canal / drug effects, physiopathology Child, Preschool Constipation / etiology* Female Hirschsprung Disease / complications, surgery* Humans Isosorbide Dinitrate / administration & dosage, therapeutic use* Male Manometry Muscle Hypertonia / complications, drug therapy* Vasodilator Agents / administration & dosage, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Traumatic rupture of hydatid cyst with unusual localization without liver involvement: a case report...
Next Document: Conjoined epigastric heteropagus twins: excision of a parasitic twin from the anterior abdominal wal...