| Topical application of imiquimod induces alterations in peripheral blood lymphocytes in healthy individuals. | |
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MedLine Citation:
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PMID: 19325996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to determine whether imiquimod, a Toll-like receptor-7/8 agonist, in addition to its well-known topical action on the cutaneous immune response, might also induce alterations in the peripheral blood lymphocytes. A 62.5 mg quantity of imiquimod (5% cream) was applied topically under occlusion once daily every second day for 3 weeks to the skin of 10 healthy volunteers, age range 30-57 years. Ten sex- and age-matched healthy controls applied corresponding quantities of the vehicle under occlusion. Before, and one and 3 weeks after the start of treatment, peripheral blood lymphocyte subpopulations were measured by flow cytometry. Statistically significant alterations in the percentage or absolute numbers of peripheral blood lymphocyte subpopulations were found in the imiquimod-treated group compared with the control group. These alterations indicate for the first time that topical application of imiquimod induces alterations in peripheral blood lymphocyte subsets in healthy individuals, which may be of importance in the immunotherapy of neoplastic and infectious disorders and should be taken into careful consideration in patients who are treated with imiquimod. |
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Authors:
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Efi Pasmatzi; Antigoni Chaidaroglou; Theophilos Sakkis; Alexandra Monastirli; Sophia Georgiou; Alexandros Sagriotis; George Badavanis; Eleftheria Vryzaki; Panagiota Matsouka; Dimitrios Degiannis; Dionysios Tsambaos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 89 ISSN: 0001-5555 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-03-27 Completed Date: 2009-05-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 134-9 Citation Subset: IM |
Affiliation:
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Department of Dermatology, School of Medicine, University of Patras, Greece. pasmatzi@med.upatras.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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administration & dosage,
pharmacology* Administration, Cutaneous Adult Aminoquinolines / administration & dosage, pharmacology* Antigens, CD / analysis HLA-DR Antigens / analysis Humans Lymphocyte Subsets / drug effects Lymphocytes / drug effects*, immunology Male Middle Aged Toll-Like Receptor 7 / agonists Toll-Like Receptor 8 / agonists |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Aminoquinolines; 0/Antigens, CD; 0/HLA-DR Antigens; 0/Toll-Like Receptor 7; 0/Toll-Like Receptor 8; 99011-02-6/imiquimod |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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