Document Detail

Topical application of green and white tea extracts provides protection from solar-simulated ultraviolet light in human skin.
MedLine Citation:
PMID:  19492999     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Tea polyphenols have been found to exert beneficial effects on the skin via their antioxidant properties. AIMS: We sought to determine whether topical application of green tea or white tea extracts would prevent simulated solar radiation-induced oxidative damages to DNA and Langerhans cells that may lead to immune suppression and carcinogenesis. METHODS: Skin samples were analysed from volunteers or skin explants treated with white tea or green tea after UV irradiation. In another group of patients, the in vivo immune protective effects of green and white tea were evaluated using contact hypersensitivity to dinitrochlorobenzene. RESULTS: Topical application of green and white tea offered protection against detrimental effects of UV on cutaneous immunity. Such protection is not because of direct UV absorption or sunscreen effects as both products showed a sun protection factor of 1. There was no significant difference in the levels of protection afforded by the two agents. Hence, both green tea and white tea are potential photoprotective agents that may be used in conjunction with established methods of sun protection.
Melissa M Camouse; Diana Santo Domingo; Freddie R Swain; Edward P Conrad; Mary S Matsui; Daniel Maes; Lieve Declercq; Kevin D Cooper; Seth R Stevens; Elma D Baron
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Experimental dermatology     Volume:  18     ISSN:  1600-0625     ISO Abbreviation:  Exp. Dermatol.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301549     Medline TA:  Exp Dermatol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  522-6     Citation Subset:  IM    
Department of Dermatology, University Hospitals Case Medical Center Cleveland, OH 44106, USA.
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MeSH Terms
Administration, Cutaneous
Antigens, CD1 / analysis
DNA Adducts / analysis
DNA Damage / drug effects
Deoxyguanosine / analogs & derivatives,  analysis
Dermatitis, Contact / etiology
Drug Evaluation, Preclinical
Flavonoids / pharmacology
Langerhans Cells / drug effects
Middle Aged
Phenols / pharmacology
Plant Extracts / pharmacology*
Skin / chemistry,  drug effects*,  radiation effects
Sunscreening Agents / pharmacology*
Tea / chemistry*,  classification
Ultraviolet Rays / adverse effects*
Young Adult
Reg. No./Substance:
0/Antigens, CD1; 0/CD1a antigen; 0/DNA Adducts; 0/Flavonoids; 0/Phenols; 0/Plant Extracts; 0/Sunscreening Agents; 0/Tea; 0/polyphenols; 88847-89-6/8-oxo-7-hydrodeoxyguanosine; 961-07-9/Deoxyguanosine; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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