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Topical application of amrinone (a selective phosphodiesterase III inhibitor) for relief of vasospasm.
MedLine Citation:
PMID:  10945957     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Amrinone, a selective phosphodiesterase III inhibitor, is an agent that possesses a combination of positive inotropic and vasodilating properties as a result of preventing the degradation of cAMP, and it has recently been licensed for the treatment of heart failure. The aim of this study was to investigate the potential therapeutic application of amrinone to resolve vasospasm, which is the major problem in reconstructive surgery. In this study its effect was compared with that of lidocaine, the most commonly used topical vasodilating agent clinically. MATERIALS AND METHODS: The probe of an ultrasonic transit-time volume flowmeter was applied to the femoral artery of rats to measure blood flow. After a baseline recording was obtained, 0.03 ml of epinephrine was applied topically to induce vasospasm. The vessels were then immersed in 1 ml of amrinone (5 mg/ml), 10% lidocaine hydrochloride, or normal physiological saline solution for 1 min in an attempt to resolve the spasm. In another group of animals, no solution was used following administration of epinephrine to allow observation of spontaneous resolution of the vasospasm over time. RESULTS: The results showed an essentially immediate spasm-resolving effect in both the amrinone group and the lidocaine group. The amrinone group showed a significantly greater degree of maximum increase in blood flow than the lidocaine group. The effect of lidocaine decreased with time, whereas amrinone had a more lasting effect. CONCLUSIONS: The findings suggest that amrinone could be used as an effective topical vasodilating agent to resolve vasospasm in reconstructive surgery.
S Ichioka; T Nakatsuka; N Ohura; Y Sato; K Harii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of surgical research     Volume:  93     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-09-22     Completed Date:  2000-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-55     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Department of Plastic and Reconstructive Surgery, Saitama Medical School, 38 Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan.
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MeSH Terms
Administration, Topical
Amrinone / administration & dosage*
Anastomosis, Surgical / adverse effects*
Lidocaine / administration & dosage
Phosphodiesterase Inhibitors / administration & dosage*
Rats, Wistar
Regional Blood Flow / drug effects
Vasoconstriction / drug effects*
Vasodilator Agents / administration & dosage*
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Vasodilator Agents; 137-58-6/Lidocaine; 60719-84-8/Amrinone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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