| Topical anti-inflammatory effect of tirucallol, a triterpene isolated from Euphorbia lactea latex. | |
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MedLine Citation:
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PMID: 19577446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Latex from Euphorbia lactea (Euphorbiaceae), a native Dominican medicinal plant, is claimed to be useful in the treatment of inflammation. Topical application of tirucallol, a tetracyclic triterpene isolated from Euphorbia lacteal latex, suppressed ear edema in the mouse model in a dose-dependent manner, as well as affecting the influx of polymorphonuclear cells in response to topical application of 12-O-tetradecanoylphorbol-acetate (TPA) in the mouse ear. In addition, the effect of tirucallol, on some macrophage functions was analyzed in vitro. Non-toxic concentrations of tirucallol potently inhibited nitrite production in lipopolysaccharide-stimulated macrophages. Western blot analysis showed that nitric oxide reduction was a consequence of the inhibition of inducible nitric oxide synthetase expression although tirucallol slightly affected to prostaglandin E(2) (PGE(2)) generation. The results of the study revealed that tirucallol (0.3%), present in Euphorbia lactea latex, exerts a topical anti-inflammatory effect in vivo, via a mechanism of action related to the neutrophil migration. On the other hand, it can be deduced that the mechanism of the anti-inflammatory activity of this triterpene is related to the control of the production of NO and its effect on the expression of iNOS. |
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Authors:
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A Fernandez-Arche; M T Saenz; M Arroyo; R de la Puerta; M D Garcia |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-03 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 17 ISSN: 1618-095X ISO Abbreviation: Phytomedicine Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 146-8 Citation Subset: IM |
Copyright Information:
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Published by Elsevier GmbH. |
Affiliation:
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Department of Pharmacology, Faculty of Pharmacy, University of Sevilla, Spain. yangzaichang@126.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Anti-Inflammatory Agents / isolation & purification, pharmacology*, therapeutic use Dinoprostone / biosynthesis Disease Models, Animal Dose-Response Relationship, Drug Edema / drug therapy*, metabolism Euphorbia / chemistry* Granulocytes / drug effects Inflammation Mediators / metabolism* Lanosterol / analogs & derivatives*, isolation & purification, pharmacology, therapeutic use Latex Lipopolysaccharides Macrophages / drug effects Male Mice Neutrophil Infiltration / drug effects* Nitric Oxide / metabolism Nitric Oxide Synthase Type II / antagonists & inhibitors Nitrites / antagonists & inhibitors Phytotherapy* Plant Extracts / chemistry, pharmacology*, therapeutic use Tetradecanoylphorbol Acetate |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Inflammation Mediators; 0/Latex; 0/Lipopolysaccharides; 0/Nitrites; 0/Plant Extracts; 0/lanostan-8,24-dien-3-ol; 10102-43-9/Nitric Oxide; 16561-29-8/Tetradecanoylphorbol Acetate; 363-24-6/Dinoprostone; 79-63-0/Lanosterol; EC 1.14.13.39/Nitric Oxide Synthase Type II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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