Document Detail

Topical anesthesia during infant eye examinations: does it reduce stress?
MedLine Citation:
PMID:  8129324     Owner:  NLM     Status:  MEDLINE    
We studied the effect of topical anesthesia on infant stress and corneal haze during the routine eye examination for retinopathy of prematurity. Using a double-blind protocol, 55 premature infants weighing less than 1501 g at birth were selected randomly to receive normal saline or proparacaine HCl 0.5% eye drops as a corneal wetting agent at their initial eye examination. Before, during, and after the procedure, infant stress was evaluated by heart rate, respiration rate, blood pressure, and transcutaneous oxygen saturation. Subjective assessment of the infant's cry intensity and corneal haze also were recorded. Adequate data were collected on 42 patients. Using analysis of variance and chi-square tests, we found no difference in any of these parameters between the two patients groups. These data suggest that topical anesthetic agents offer no advantage over normal saline eye drops during the examination of premature infants.
R A Saunders; K W Miller; H H Hunt
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of ophthalmology     Volume:  25     ISSN:  0003-4886     ISO Abbreviation:  Ann Ophthalmol     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0210137     Medline TA:  Ann Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
Department of Ophthalmology, Medical University of South Carolina, Charleston.
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MeSH Terms
Administration, Topical
Anesthesia, Local*
Cornea / drug effects
Double-Blind Method
Hemodynamics / drug effects
Infant, Newborn
Infant, Premature
Ophthalmic Solutions
Propoxycaine / administration & dosage*
Prospective Studies
Retinopathy of Prematurity / diagnosis*
Stress, Physiological / prevention & control*
Reg. No./Substance:
0/Ophthalmic Solutions; 499-67-2/proxymetacaine; 86-43-1/Propoxycaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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