| Topical ampicillin for prophylaxis against wound infection in acute appendicitis. | |
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MedLine Citation:
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PMID: 17586899 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A total of 249 patients, undergoing appendectomy for acute appendicitis, were prospectively randomized into two groups. Group I, comprising 132 patients, received sterile normal saline irrigation to the surgical wound at closure. Alternatively, Group II included 117 patients, who received intraoperative topical ampicillin irrigation of the wound. Both groups were comparable with regard to age, sex, duration of symptoms, and severity of appendicitis. All patients additionally received preoperative systemic gentamicin and Flagyl. Wound infection occurred in 5.3% of Group I compared to only 0.9% of Group II (P<0.05). The reduction in infection rate was significant (P<0.05) in histologically proven appendicitis. We conclude that the addition of intraoperative topical ampicillin to systemic gentamicin and Flagyl augments prophylaxis against wound infection in acute appendicitis. |
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Authors:
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M Y Al-Shehri; S Saif; A Ibrahim; S Abu-Eshy; T Al-Malki; A A Latif; T Malatani; A Al-Saigh; A Al-Nami; A Batouk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of Saudi medicine Volume: 14 ISSN: 0256-4947 ISO Abbreviation: Ann Saudi Med Publication Date: 1994 May |
Date Detail:
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Created Date: 2007-06-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507355 Medline TA: Ann Saudi Med Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 233-6 Citation Subset: - |
Affiliation:
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Department of Surgery, King Saud University-Abha Branch, College of Medicine, Abha, Saudi Arabia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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