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Topical ampicillin for prophylaxis against wound infection in acute appendicitis.
MedLine Citation:
PMID:  17586899     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A total of 249 patients, undergoing appendectomy for acute appendicitis, were prospectively randomized into two groups. Group I, comprising 132 patients, received sterile normal saline irrigation to the surgical wound at closure. Alternatively, Group II included 117 patients, who received intraoperative topical ampicillin irrigation of the wound. Both groups were comparable with regard to age, sex, duration of symptoms, and severity of appendicitis. All patients additionally received preoperative systemic gentamicin and Flagyl. Wound infection occurred in 5.3% of Group I compared to only 0.9% of Group II (P<0.05). The reduction in infection rate was significant (P<0.05) in histologically proven appendicitis. We conclude that the addition of intraoperative topical ampicillin to systemic gentamicin and Flagyl augments prophylaxis against wound infection in acute appendicitis.
Authors:
M Y Al-Shehri; S Saif; A Ibrahim; S Abu-Eshy; T Al-Malki; A A Latif; T Malatani; A Al-Saigh; A Al-Nami; A Batouk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  14     ISSN:  0256-4947     ISO Abbreviation:  Ann Saudi Med     Publication Date:  1994 May 
Date Detail:
Created Date:  2007-06-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  233-6     Citation Subset:  -    
Affiliation:
Department of Surgery, King Saud University-Abha Branch, College of Medicine, Abha, Saudi Arabia.
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