Document Detail

Topical acetazolamide and methazolamide delivered by contact lenses.
MedLine Citation:
PMID:  3860197     Owner:  NLM     Status:  MEDLINE    
Topical acetazolamide has been previously found to be ineffective in lowering intraocular pressure (IOP). Using high-water-content soft contact lenses (Sauflon PW) soaked in acetazolamide, we observed a statistically significant ipsilateral decrease in IOP of 6.3 +/- 0.4 mm Hg in the treated eyes of albino rabbits. The duration of the effect was up to 7 1/2 hours. Methazolamide-soaked contact lenses produced a maximum unilateral reduction of similar magnitude but shorter duration. Both serum and aqueous humor analyses for pH, carbon dioxide pressure, bicarbonate, and base excess indicate that acetazolamide delivered by soft contact lenses is able to penetrate the cornea in sufficient concentration to lower IOP by a local mechanism in rabbits without significant systemic absorption.
Z Friedman; R C Allen; S M Raph
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  103     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-09     Completed Date:  1985-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  963-6     Citation Subset:  AIM; IM    
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MeSH Terms
Acetazolamide / administration & dosage*,  pharmacology
Administration, Topical
Blood Chemical Analysis
Contact Lenses, Extended-Wear*
Contact Lenses, Hydrophilic*
Intraocular Pressure / drug effects
Methazolamide / administration & dosage*,  pharmacology
Thiadiazoles / administration & dosage*
Reg. No./Substance:
0/Thiadiazoles; 554-57-4/Methazolamide; 59-66-5/Acetazolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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