Document Detail

Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial.
MedLine Citation:
PMID:  20679835     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Silicone sheets are widely used in the treatment of hypertrophic scars, although application around joints may cause limited adherence and reduced movement. To approach these problems, a topical silicone gel was developed that can be applied easily in a thin layer, and that is nonrestrictive and less apparent. The objective of this study was to investigate the effectiveness of topical silicone gel in promoting the maturation of burn scars.
METHODS: Forty-six scars on 23 patients were included in a randomized, placebo-controlled, within-subject comparative, double-blinded, clinical trial and followed for 1 year. The mean age of the scars at inclusion was 4 months. Effectiveness on scar quality was evaluated using the Patient and Observer Scar Assessment Scale and the DermaSpectrometer. Significance was tested using repeated measures analyses and Wilcoxon paired-sample signed rank tests.
RESULTS: Over all visits, the benefit on surface roughness was statistically significant (p = 0.012). At individual time points, the surface of the topical silicone gel-treated scars showed significantly less roughness (p = 0.014) at 3 months after start of the treatment, and the topical silicone gel-treated scars were significantly less itchy (p = 0.018 and p = 0.013, respectively) at 3 and 6 months.
CONCLUSION: Topical silicone gel significantly improves the surface roughness of burn scars, and patients experience significantly less itching in the first half year after application.
Martijn B A van der Wal; Paul P van Zuijlen; Peter van de Ven; Esther Middelkoop
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Plastic and reconstructive surgery     Volume:  126     ISSN:  1529-4242     ISO Abbreviation:  Plast. Reconstr. Surg.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-03     Completed Date:  2010-09-15     Revised Date:  2014-10-13    
Medline Journal Info:
Nlm Unique ID:  1306050     Medline TA:  Plast Reconstr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  524-31     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Topical
Burns / complications*,  diagnosis,  therapy
Cicatrix, Hypertrophic / etiology*,  pathology,  therapy*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Follow-Up Studies
Injury Severity Score
Middle Aged
Observer Variation
Prospective Studies
Reference Values
Risk Assessment
Silicone Gels / therapeutic use*
Skin Absorption / physiology
Spectrum Analysis
Statistics, Nonparametric
Time Factors
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Silicone Gels
Comment In:
Plast Reconstr Surg. 2011 Aug;128(2):607; author reply 607   [PMID:  21788884 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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