Document Detail


Topical drug formulations for prolonged corneal anesthesia.
MedLine Citation:
PMID:  23615270     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Ocular local anesthetics currently used in routine clinical practice for corneal anesthesia are short acting and their ability to delay corneal healing makes them unsuitable for long-term use. In this study, we examined the effect of the site 1 sodium channel blocker tetrodotoxin (TTX) on the duration of corneal anesthesia, applied with either proparacaine (PPC) or the chemical permeation enhancer octyl-trimethyl ammonium bromide (OTAB). The effect of test solutions on corneal healing was also studied.
METHODS: Solutions of TTX, PPC, and OTAB, singly or in combination, were applied topically to the rat cornea. The blink response, an indirect measure of corneal sensitivity, was recorded using a Cochet-Bonnet esthesiometer, and the duration of corneal anesthesia was calculated. The effect of test compounds on the rate of corneal epithelialization was studied in vivo after corneal debridement.
RESULTS: Combination of TTX and PPC resulted in corneal anesthesia that was 8 to 10 times longer in duration than that from either drug administered alone, whereas OTAB did not prolong anesthesia. The rate of corneal healing was moderately delayed after coadministration of TTX and PPC.
CONCLUSIONS: Coadministration of TTX and PPC significantly prolonged corneal anesthesia, but in view of delayed corneal reepithelialization, caution is suggested in the use of the drug combination.
Authors:
Liqiang Wang; Sahadev A Shankarappa; Rong Tong; Joseph B Ciolino; Jonathan H Tsui; Homer H Chiang; Daniel S Kohane
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cornea     Volume:  32     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2014-01-08     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1040-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, Local / methods*
Anesthetics, Combined
Anesthetics, Local / pharmacology*
Animals
Cell Line
Chemistry, Pharmaceutical
Cornea / drug effects*,  physiology
Corneal Keratocytes / drug effects
Epithelium, Corneal / drug effects
Humans
Male
Propoxycaine / pharmacology*
Quaternary Ammonium Compounds / pharmacology
Rats
Rats, Sprague-Dawley
Sodium Channel Blockers / pharmacology*
Tetrodotoxin / pharmacology*
Time Factors
Wound Healing / drug effects
Grant Support
ID/Acronym/Agency:
GM 073626/GM/NIGMS NIH HHS; K08 EY019686/EY/NEI NIH HHS; R01 GM073626/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Combined; 0/Anesthetics, Local; 0/Quaternary Ammonium Compounds; 0/Sodium Channel Blockers; 15461-38-8/octyltrimethylammonium; 4368-28-9/Tetrodotoxin; B4OB0JHI1X/proxymetacaine; EPD1EH7F53/Propoxycaine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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