Document Detail

Topical Biafine and Lipiderm for the prevention of radiation dermatitis: a randomized prospective trial.
MedLine Citation:
PMID:  11182045     Owner:  NLM     Status:  MEDLINE    
We evaluated the effects of Biafine and Lipiderm ointments in preventing radiation dermatitis. The study population included 74 patients after conservative surgery for early breast carcinoma who were referred for adjuvant external beam irradiation. Patients were randomized to receive Biafine or Lipiderm or no treatment. Both study preparations were applied twice daily, starting 10 days before onset of radiotherapy and continuing until 10 days after its completion. The skin treatment was upgraded, if clinically necessary, to steroids (grade 3), antibiotics (grade 4), or pause in therapy (grade 5). Success of treatment was evaluated according to the maximal level of skin treatment, the number of gaps in radiation therapy, the impression of the patients and the subjective skin reaction, and scores of the study nurse and radiotherapist. The three groups were comparable for all clinical features, except for a lower mean age of the Biafine group. Comparative analysis of the results showed no advantage for either preparation compared to the control arm other than maximal treatment level required for a skin reaction (mean 1.7 and 1.6 vs. 2.2), which did not reach statistical significance (p=0.145). Nevertheless, 86% of the patients in both the Biafine and Lipiderm arms expressed satisfaction with the respective ointments. In conclusion, neither Biafine nor Lipiderm seems to have a radioprotective effect.
E Fenig; B Brenner; A Katz; J Sulkes; M Lapidot; J Schachter; H Malik; A Sulkes; H Gutman
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Oncology reports     Volume:  8     ISSN:  1021-335X     ISO Abbreviation:  Oncol. Rep.     Publication Date:    2001 Mar-Apr
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422756     Medline TA:  Oncol Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  IM    
Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel.
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MeSH Terms
Administration, Topical
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal / adverse effects,  therapeutic use*
Antineoplastic Agents, Hormonal / therapeutic use
Breast Neoplasms / drug therapy,  radiotherapy*,  surgery
Combined Modality Therapy
Dermatologic Agents / adverse effects,  therapeutic use*
Ethnic Groups
Fatty Acids / adverse effects,  therapeutic use*
Mastectomy, Segmental
Middle Aged
Neoplasm Staging
Radiodermatitis / prevention & control*
Radiotherapy / adverse effects*
Sesquiterpenes / adverse effects,  therapeutic use*
Skin Pigmentation
Tamoxifen / therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antineoplastic Agents, Hormonal; 0/Biafine; 0/Dermatologic Agents; 0/Fatty Acids; 0/Lipiderm; 0/Lipids; 0/Sesquiterpenes; 10540-29-1/Tamoxifen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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