| Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 21789959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes. |
| | |
Authors:
|
Sibel Yildirim; Susan Y Fu; Keith Kim; Hong Zhou; Chang Hun Lee; Ang Li; Sahng Gyoon Kim; Shuang Wang; Jeremy J Mao |
Related Documents
:
|
21727069 - Experimental results of using autologous rectus fascia sheath for venous patch grafts i... 23053799 - Layered double hydroxides as efficient drug delivery system of ciprofloxacin in the mid... 21691579 - Acute endothelial failure after cosmetic iris implants (newiris®). 18024469 - Effects of experimental occlusal hypofunction, and its recovery, on mandibular bone min... 7634629 - Femoral bone loss following hip replacement. a comparative study. 17875599 - Precision of lunar achilles+ bone quality measurements: time dependency and multiple ma... 15936809 - Relationship between in vitro fertilisation of ewe oocytes and the fertility of ewes fo... 14761899 - Biological risks of resin-based materials to the dentin-pulp complex. 19085239 - Transgenic overexpression of gremlin results in developmental defects in enamel and den... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: International journal of oral science Volume: 3 ISSN: 1674-2818 ISO Abbreviation: Int J Oral Sci Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-07-27 Completed Date: 2011-08-23 Revised Date: 2012-10-15 |
Medline Journal Info:
|
Nlm Unique ID: 101504351 Medline TA: Int J Oral Sci Country: China |
Other Details:
|
Languages: eng Pagination: 107-16 Citation Subset: D; IM |
Affiliation:
|
Tissue Engineering and Regenerative Medicine Laboratory (TERML), Center for Craniofacial Regeneration, Columbia University Medical Center, New York, NY 10032, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Stem Cells Animals Humans Regeneration* Regenerative Medicine* Signal Transduction Stem Cell Transplantation Tissue Engineering Tissue Scaffolds Tooth / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
RC2DE020767/RC/CCR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): Int J Oral Sci Journal ID (iso-abbrev): Int J Oral Sci ISSN: 1674-2818 ISSN: 2049-3169 Publisher: Nature Publishing Group |
Article Information Download PDF  Copyright © 2011 West China School of Stomatology open-access: Received Day: 28 Month: 12 Year: 2010 Accepted Day: 30 Month: 03 Year: 2011 Print publication date: Month: 07 Year: 2011 pmc-release publication date: Day: 1 Month: 7 Year: 2011 Volume: 3 Issue: 3 First Page: 107 Last Page: 116 ID: 3470096 Publisher Item Identifier: ijos201116 DOI: 10.4248/IJOS11042 PubMed Id: 21789959 |
| Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine | |
| Sibel Yildirim1 | |
| Susan Y Fu1 | |
| Keith Kim1 | |
| Hong Zhou2 | |
| Chang Hun Lee1 | |
| Ang Li2 | |
| Sahng Gyoon Kim1 | |
| Shuang Wang2 | |
| Jeremy J Mao1* | |
|
1Tissue Engineering and Regenerative Medicine Laboratory (TERML), Center for Craniofacial Regeneration, Columbia University Medical Center, New York, NY 10032, USA |
|
|
2Department of Basic Science, Xi'an Jiaotong University School of Stomatology, Xi'an 710049, China |
|
| *Fax: 001 212 342 0199 E-mail: jmao@columbia.edu |
|
Article Categories:
Keywords: stem cells, bioactive cues, biomaterials, cell homing, dental pulp, tooth regeneration, growth factors, scaffold, dental implants, pulp regeneration. |
|
Previous Document: The chemical characterization of the gene: vicissitudes of evidential assessment.
Next Document: Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissue...