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Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine.
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MedLine Citation:
PMID:  21789959     Owner:  NLM     Status:  MEDLINE    
A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes.
Sibel Yildirim; Susan Y Fu; Keith Kim; Hong Zhou; Chang Hun Lee; Ang Li; Sahng Gyoon Kim; Shuang Wang; Jeremy J Mao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  International journal of oral science     Volume:  3     ISSN:  1674-2818     ISO Abbreviation:  Int J Oral Sci     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-08-23     Revised Date:  2012-10-15    
Medline Journal Info:
Nlm Unique ID:  101504351     Medline TA:  Int J Oral Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  D; IM    
Tissue Engineering and Regenerative Medicine Laboratory (TERML), Center for Craniofacial Regeneration, Columbia University Medical Center, New York, NY 10032, USA.
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MeSH Terms
Adult Stem Cells
Regenerative Medicine*
Signal Transduction
Stem Cell Transplantation
Tissue Engineering
Tissue Scaffolds
Tooth / physiology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Int J Oral Sci
Journal ID (iso-abbrev): Int J Oral Sci
ISSN: 1674-2818
ISSN: 2049-3169
Publisher: Nature Publishing Group
Article Information
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Copyright © 2011 West China School of Stomatology
Received Day: 28 Month: 12 Year: 2010
Accepted Day: 30 Month: 03 Year: 2011
Print publication date: Month: 07 Year: 2011
pmc-release publication date: Day: 1 Month: 7 Year: 2011
Volume: 3 Issue: 3
First Page: 107 Last Page: 116
ID: 3470096
Publisher Item Identifier: ijos201116
DOI: 10.4248/IJOS11042
PubMed Id: 21789959

Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine
Sibel Yildirim1
Susan Y Fu1
Keith Kim1
Hong Zhou2
Chang Hun Lee1
Ang Li2
Sahng Gyoon Kim1
Shuang Wang2
Jeremy J Mao1*
1Tissue Engineering and Regenerative Medicine Laboratory (TERML), Center for Craniofacial Regeneration, Columbia University Medical Center, New York, NY 10032, USA
2Department of Basic Science, Xi'an Jiaotong University School of Stomatology, Xi'an 710049, China
*Fax: 001 212 342 0199 E-mail:

Article Categories:
  • Review

Keywords: stem cells, bioactive cues, biomaterials, cell homing, dental pulp, tooth regeneration, growth factors, scaffold, dental implants, pulp regeneration.

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