Document Detail

Tooth agenesis: from molecular genetics to molecular dentistry.
MedLine Citation:
PMID:  18573979     Owner:  NLM     Status:  MEDLINE    
Tooth agenesis may originate from either genetic or environmental factors. Genetically determined hypodontic disorders appear as isolated features or as part of a syndrome. Msx1, Pax9, and Axin2 are involved in non-syndromic hypodontia, while genes such as Shh, Pitx2, Irf6, and p63 are considered to participate in syndromic genetic disorders, which include tooth agenesis. In dentistry, artificial tooth implants represent a common solution to tooth loss problems; however, molecular dentistry offers promising solutions for the future. In this paper, the genetic and molecular bases of non-syndromic and syndromic hypodontia are reviewed, and the advantages and disadvantages of tissue engineering in the clinical treatment of tooth agenesis are discussed.
E Matalova; J Fleischmannova; P T Sharpe; A S Tucker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of dental research     Volume:  87     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  617-23     Citation Subset:  D; IM    
Institute of Animal Physiology and Genetics, Academy of Sciences, Brno, Czech Republic.
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MeSH Terms
Anodontia / complications,  genetics*,  therapy
Dentistry / trends
Mouth Abnormalities / complications,  genetics
Odontogenesis / genetics*
Tissue Engineering / trends*
Tooth Germ / physiology

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