Document Detail

Tools for tissue engineering of mineralized oral structures.
MedLine Citation:
PMID:  11218500     Owner:  NLM     Status:  MEDLINE    
This paper presents a short review of three groups of tools which can be or are used for the tissue engineering of mineralized oral structures: growth factor delivery systems (GFDS) and surface bioactivation with covalent bound peptides or with nanomechanically linked proteins. According to the reported personal experience of the authors, GFDS have to face the following challenging issue before being used routinely in dentistry, e.g., as a tool for reparative dentinogenesis or bone healing: adaptation of the GFDS design to the tissue where it will be implanted in order to deliver the right dose of growth factor (GF) at the right time. The bioactivation of surfaces, for example of dental implants, with covalent bound peptides or nanomechanically linked proteins represents a second innovative way to improve dental health in the future. Here we report on the experimental use of cyclic RGD peptides grafted on polymethylmethacrylate to improve osteoblast adhesion. Furthermore, we show the potential advantage of immobilizing and incorporating collagen I on titanium implant surfaces. These techniques or a combination of them will help to create improvements, for example, of dental implants in the near future. They will also help to promote bone and dentin regeneration.
M Dard; A Sewing; J Meyer; S Verrier; S Roessler; D Scharnweber
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical oral investigations     Volume:  4     ISSN:  1432-6981     ISO Abbreviation:  Clin Oral Investig     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2001-02-20     Completed Date:  2001-03-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9707115     Medline TA:  Clin Oral Investig     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  126-9     Citation Subset:  D    
Merck Biomaterial, Frankfurter Strasse 250, 64271 Darmstadt, Germany.
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MeSH Terms
Alveolar Process / drug effects*
Amino Acid Sequence
Bone Regeneration / drug effects
Cell Adhesion
Coated Materials, Biocompatible / chemistry
Collagen / chemistry
Dental Implants
Dentin, Secondary / chemically induced
Dentinogenesis / drug effects
Drug Delivery Systems
Growth Substances / administration & dosage,  therapeutic use*
Oligopeptides / chemistry
Osteoblasts / cytology
Polymethyl Methacrylate / chemistry
Protein Binding
Receptors, Immunologic / chemistry
Surface Properties
Titanium / chemistry
Tooth / drug effects*
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Dental Implants; 0/Growth Substances; 0/Oligopeptides; 0/Receptors, Immunologic; 7440-32-6/Titanium; 9007-34-5/Collagen; 9011-14-7/Polymethyl Methacrylate; 99896-85-2/arginyl-glycyl-aspartic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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