| Too rapid increase and too much breathlessness are distinct indices of exertional dyspnea in COPD. | |
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MedLine Citation:
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PMID: 21262394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess whether different indices of dyspnea can be obtained from cardiopulmonary exercise test and whether these indices correlate with distinct physiological parameters in COPD. Forty-two COPD patients (12 females, median [IQ] age 66 [56-70] years; FEV(1)% predicted: 51 [38-65]) underwent pulmonary function and incremental exercise tests. A power law function described the oxygen consumption (V(O₂)-Dyspnea relationship from which two indices correlated with MRC score: dyspnea score measured at 50% of predicted V(O₂) (too much breathless for that effort) and tangent measured at 50% of peak dyspnea (too rapid increase in dyspnea at this time point). The former independently correlated with ventilation on exercise, while the latter independently correlated with baseline hyperinflation. An upward shift of both (iso)-V(O₂) and -ventilation was evidenced in patients with higher levels of dyspnea (MRC score ≥ 3) and their tangents were significantly different. In conclusion, baseline hyperinflation is associated with the perception of a too rapid increase in dyspnea on exercise in COPD. |
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Authors:
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Christophe Delclaux; Brigitte Chevalier-Bidaud; Mohamed Essalhi; Etienne Callens; Semia Graba; Karine Gillet-Juvin; Judith Valcke-Brossollet; Bruno Mahut |
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Publication Detail:
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Type: Journal Article Date: 2011-01-22 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 176 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-11 Completed Date: 2011-07-06 Revised Date: 2011-12-14 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 32-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Service de Physiologie-Clinique de la Dyspnée, Paris, France. christophe.delclaux@egp.aphp.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cross-Sectional Studies Dyspnea / physiopathology* Exercise / physiology* Exercise Test Female Humans Male Middle Aged Physical Exertion / physiology* Pulmonary Disease, Chronic Obstructive / physiopathology* Respiratory Function Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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