Document Detail

Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors.
MedLine Citation:
PMID:  17992659     Owner:  NLM     Status:  MEDLINE    
Palmoplantar pustulosis (PPP) is an autoimmune disease characterized by psoriasis-like erythematous lesions on palms and/or soles due to an abnormal humoral immune response. Tonsillectomy is effectively employed for the treatment of PPP; however, how tonsils are involved in the aetiology of PPP remains unclear. Here we analysed surgically resected palatine tonsils from 36 cases of PPP as well as usual recurrent tonsillitis (RT) as a control. Histological examination revealed that a unique lesion, with lymphoid follicles surrounded by reticular crypt epithelial cells, was more frequently observed in tonsils of patients with PPP than in those with RT (p < 0.0001; PPP vs RT). Interestingly, crypt epithelial cells in primary cultures derived from PPP tonsils showed marked production of interleukin-6 (IL-6). Moreover, these epithelial cells from PPP tonsils expressed p53-related transcription factors in their nuclei that were found to contribute to the up-regulation of IL-6 gene expression. These findings suggest that, at least in part, the specialized lymphoepithelial symbiosis of PPP tonsils, under the control of p53-related factors, may be relevant to the generation of the impaired micro-environment underlying the aberrant production of autoantibodies.
S Koshiba; S Ichimiya; T Nagashima; A Tonooka; T Kubo; T Kikuchi; T Himi; N Sato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pathology     Volume:  214     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-13     Completed Date:  2008-02-15     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.
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MeSH Terms
Autoimmune Diseases / immunology*,  pathology
B-Lymphocytes / immunology*
Cell Culture Techniques
Child, Preschool
DNA-Binding Proteins / immunology
Epithelial Cells / immunology,  physiology
Interleukin-6 / biosynthesis*,  genetics
Membrane Proteins / immunology
Middle Aged
Nuclear Proteins / immunology
Palatine Tonsil / immunology*
Postoperative Period
Psoriasis / immunology*,  pathology
Tonsillitis / immunology*,  pathology,  surgery
Tumor Suppressor Proteins / immunology
Reg. No./Substance:
0/CKAP4 protein, human; 0/DNA-Binding Proteins; 0/Interleukin-6; 0/Membrane Proteins; 0/Nuclear Proteins; 0/Tumor Suppressor Proteins; 0/tumor suppressor protein p73

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