| Tonsillar crypt epithelium of palmoplantar pustulosis secretes interleukin-6 to support B-cell development via p63/p73 transcription factors. | |
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MedLine Citation:
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PMID: 17992659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Palmoplantar pustulosis (PPP) is an autoimmune disease characterized by psoriasis-like erythematous lesions on palms and/or soles due to an abnormal humoral immune response. Tonsillectomy is effectively employed for the treatment of PPP; however, how tonsils are involved in the aetiology of PPP remains unclear. Here we analysed surgically resected palatine tonsils from 36 cases of PPP as well as usual recurrent tonsillitis (RT) as a control. Histological examination revealed that a unique lesion, with lymphoid follicles surrounded by reticular crypt epithelial cells, was more frequently observed in tonsils of patients with PPP than in those with RT (p < 0.0001; PPP vs RT). Interestingly, crypt epithelial cells in primary cultures derived from PPP tonsils showed marked production of interleukin-6 (IL-6). Moreover, these epithelial cells from PPP tonsils expressed p53-related transcription factors in their nuclei that were found to contribute to the up-regulation of IL-6 gene expression. These findings suggest that, at least in part, the specialized lymphoepithelial symbiosis of PPP tonsils, under the control of p53-related factors, may be relevant to the generation of the impaired micro-environment underlying the aberrant production of autoantibodies. |
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Authors:
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S Koshiba; S Ichimiya; T Nagashima; A Tonooka; T Kubo; T Kikuchi; T Himi; N Sato |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of pathology Volume: 214 ISSN: 0022-3417 ISO Abbreviation: J. Pathol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-13 Completed Date: 2008-02-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0204634 Medline TA: J Pathol Country: England |
Other Details:
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Languages: eng Pagination: 75-84 Citation Subset: IM |
Affiliation:
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Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Autoimmune Diseases / immunology*, pathology B-Lymphocytes / immunology* Cell Culture Techniques Child, Preschool DNA-Binding Proteins / immunology Epithelial Cells / immunology, physiology Female Humans Interleukin-6 / biosynthesis*, genetics Male Membrane Proteins / immunology Middle Aged Nuclear Proteins / immunology Palatine Tonsil / immunology* Postoperative Period Psoriasis / immunology*, pathology Recurrence Tonsillectomy Tonsillitis / immunology*, pathology, surgery Tumor Suppressor Proteins / immunology Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/CKAP4 protein, human; 0/DNA-Binding Proteins; 0/Interleukin-6; 0/Membrane Proteins; 0/Nuclear Proteins; 0/Tumor Suppressor Proteins; 0/tumor suppressor protein p73 |
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