Document Detail

Tonotopic changes in GABA receptor expression in guinea pig inferior colliculus after partial unilateral hearing loss.
MedLine Citation:
PMID:  20438718     Owner:  NLM     Status:  MEDLINE    
Immunohistochemistry was used to investigate the topographic distribution of the alpha1 subunit of the GABA receptor (GABRA1) in guinea pig inferior colliculus after treatments that caused a unilateral loss of peripheral neural sensitivity in the high-frequency regions of the cochlea. Both forms of treatment (direct mechanical lesion of the cochlea and acoustic overstimulation) resulted in a significant decrease in GABRA1 labeling in regions of the contralateral inferior colliculus in which high-frequency sound stimuli are represented. This localized region of reduced inhibitory receptor expression corresponds to the region in which hyperactivity of inferior colliculus neurons has been shown to develop after such treatments. The results strengthen the notion of a causal link between reduced GABRA1 expression and neural hyperactivity in central auditory nuclei and provide a possible mechanism for the development of phantom auditory sensations, or tinnitus.
S Dong; J Rodger; W H A M Mulders; D Robertson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-23
Journal Detail:
Title:  Brain research     Volume:  1342     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2011-01-18     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  24-32     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Discipline of Physiology M311, School of Biomedical Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.
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MeSH Terms
Auditory Pathways / metabolism*,  physiopathology
Auditory Perception / physiology*
Guinea Pigs
Hearing Loss, Unilateral / complications*,  physiopathology
Inferior Colliculi / metabolism*,  physiopathology
Neural Inhibition / physiology
Pitch Perception / physiology
Receptors, GABA-A / metabolism*
Synaptic Transmission / physiology
Tinnitus / etiology,  physiopathology
gamma-Aminobutyric Acid / metabolism*
Grant Support
G37//Action on Hearing Loss
Reg. No./Substance:
0/Receptors, GABA-A; 56-12-2/gamma-Aminobutyric Acid

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