Document Detail

Tonic sympathoinhibition arising from the hypothalamic PVN in the conscious rabbit.
MedLine Citation:
PMID:  12144848     Owner:  NLM     Status:  MEDLINE    
In the conscious rabbit muscimol (1-10 nmol/side) was microinjected into the hypothalamic paraventricular nucleus to inhibit neuronal function and the acute changes in mean arterial pressure (MAP), heart rate and renal sympathetic nerve activity (RSNA) were monitored. Muscimol (1 nmol) had no effect on the cardiovascular variables, as was the case with vehicle. However, muscimol (10 nmol) elicited a significant increase in RSNA of 184+/-40% and a reduction in heart rate of 49+/-12 beats/min but no change in MAP. The effect of blocking endogenous glutamatergic inputs with the glutamate antagonist, kynurenate (25 nmol), into the PVN was also examined. Kynurenate elicited an increase in RSNA of 35+/-9% with no significant change in MAP or HR. The results suggest that muscimol inhibits a tonically active inhibitory influence on RSNA arising from the PVN in the conscious rabbit. A glutamatergic input into the PVN appears to contribute to the tonic activation of this inhibitory influence.
Emilio Badoer; Chi-Wai Ng; Robert De Matteo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  947     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-29     Completed Date:  2002-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
School of Medical Sciences, Division of Biosciences, RMIT University, PO Box 71, Bundoora 3083, Melbourne, Victoria, Australia.
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MeSH Terms
Blood Pressure / physiology
Brain / anatomy & histology
Electrodes, Implanted
Excitatory Amino Acid Antagonists / administration & dosage,  pharmacology
GABA Agonists / administration & dosage,  pharmacology
Heart Rate / physiology
Kidney / drug effects,  innervation
Kynurenic Acid / administration & dosage,  pharmacology
Muscimol / administration & dosage,  pharmacology
Paraventricular Hypothalamic Nucleus / anatomy & histology,  physiology*
Sympathetic Nervous System / physiology*
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/GABA Agonists; 2763-96-4/Muscimol; 492-27-3/Kynurenic Acid

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