| Tongxinluo inhibits oxidized low-density lipoprotein-induced maturation of human dendritic cells via activating peroxisome proliferator-activated receptor gamma pathway. | |
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MedLine Citation:
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PMID: 20489656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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TongXinLuo (TXL) is a traditional Chinese herbal medicine with multiple vasoprotective activities. Dendritic cells (DCs) play an active role in the immunological processes related to atherosclerosis. The purpose of this study was to determine the effect and possible mechanisms of TXL on oxidized low-density lipoprotein (OX-LDL)-induced maturation and immune function of DCs. Human monocyte-derived DCs were incubated with TXL or ciglitazone and were subsequently stimulated with OX-LDL to induce maturation. Similar to ciglitazone, a peroxisome proliferator-activated receptor (PPAR) gamma agonist, TXL could significantly reduce the maturation-associated markers induced by OX-LDL, such as CD40, CD86, CD1a, and human leukocyte antigen-DR; improved the endocytotic function; and decreased secretions of cytokine interleukin-12 and tumor necrosis factor alpha. These inhibitory effects of TXL could be partly reversed by silencing the expression of PPAR gamma in DCs. In conclusion, TXL could inhibit OX-LDL-induced maturation of DCs through activating PPAR gamma pathway. |
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Authors:
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Wei Su; Aijun Sun; Danling Xu; Hongqi Zhang; Lin Yang; Lingyan Yuan; Jianguo Jia; Yunzeng Zou; Yiling Wu; Keqiang Wang; Junbo Ge |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 56 ISSN: 1533-4023 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-26 Completed Date: 2010-12-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 177-83 Citation Subset: IM |
Affiliation:
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Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD1
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metabolism Antigens, CD40 / metabolism Antigens, CD86 / metabolism Cells, Cultured Dendritic Cells / drug effects*, immunology, metabolism Drugs, Chinese Herbal / pharmacology* Endocytosis HLA-DR Antigens / immunology, metabolism Humans Interleukin-12 / antagonists & inhibitors, secretion Lipoproteins, LDL / antagonists & inhibitors*, physiology PPAR gamma / agonists*, metabolism Thiazolidinediones / pharmacology Tumor Necrosis Factor-alpha / antagonists & inhibitors, secretion |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD1; 0/Antigens, CD40; 0/Antigens, CD86; 0/CD1a antigen; 0/Drugs, Chinese Herbal; 0/HLA-DR Antigens; 0/Lipoproteins, LDL; 0/PPAR gamma; 0/Thiazolidinediones; 0/Tumor Necrosis Factor-alpha; 0/oxidized low density lipoprotein; 0/tongxinluo; 187348-17-0/Interleukin-12; 74772-77-3/ciglitazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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