Document Detail


Tone-dependent vasodilator responses to proadrenomedullin NH2-terminal 20 peptide in the hindquarters vascular bed of the rat.
MedLine Citation:
PMID:  9210169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Responses to proadrenomedullin NH2-terminal 20 peptide (PAMP) were investigated in the systemic and hindquarters vascular bed of the rat. Intravenous injections of PAMP and adrenomedullin (ADM) produced dose-related decreases in systemic arterial and hindquarters perfusion pressure, which were not altered by alpha-receptor or adrenergic nerve terminal blocking agents. PAMP was 100-fold less potent than ADM, and hindquarters vasodilator responses to both peptides were similar in innervated and denervated preparations. When baseline tone was increased with phenylephrine and U46619 or decreased with sodium nitroprusside, vasodilator responses to PAMP and ADM were correlated with the basal level of tone, suggesting that responses to both peptides are dependent on the baseline level of vasoconstrictor tone in the hindquarters vascular bed of the rat.
Authors:
H C Champion; M A Czapla; D E Friedman; D G Lambert; W A Murphy; D H Coy; P J Kadowitz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Peptides     Volume:  18     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1997  
Date Detail:
Created Date:  1997-09-11     Completed Date:  1997-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  513-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenomedullin
Animals
Drug Evaluation, Preclinical
Endothelium, Vascular / drug effects*,  innervation
Hindlimb / blood supply*,  innervation
Muscle Tonus / physiology*
Norepinephrine / pharmacology
Peptide Fragments / pharmacology*
Peptides / pharmacology*
Proteins / pharmacology*
Rats
Rats, Sprague-Dawley
Sympathetic Nervous System / physiology
Vasoconstriction / drug effects
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Peptide Fragments; 0/Peptides; 0/Proteins; 0/Vasodilator Agents; 148498-78-6/Adrenomedullin; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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