Document Detail


Tomographic studies of rCBF with [99mTc]-HM-PAO SPECT in patients with brain tumors: comparison with C15O2 continuous inhalation technique and PET.
MedLine Citation:
PMID:  2848045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 10 patients with malignant gliomas, the intracerebral distribution of [99mTc]-hexamethylpropylene-amine oxime [( 99mTc]-HM-PAO) was studied with single photon emission computed tomography (SPECT) in comparison with C15O2 steady-state inhalation technique to measure cerebral blood flow using positron emission tomography (PET). In all instances, the cerebral [99mTc]-HM-PAO distribution was comparable with the regional pattern of cerebral blood flow (rCBF) observed with PET. This was confirmed by a significant correlation of tumor to cortex and tumor to white matter ratios between these two experimental methods. However, the contrast between high and low activity regions in the SPECT scans was significantly less than that in the PET scans. Contrast enhancement of the SPECT scans was accomplished using a correction formula proposed by Lassen.
Authors:
K J Langen; H Herzog; T Kuwert; N Roosen; E Rota; J C Kiwit; W J Bock; L E Feinendegen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  8     ISSN:  0271-678X     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-06     Completed Date:  1989-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S90-4     Citation Subset:  IM    
Affiliation:
Institute of Medicine, Nuclear Research Center Jülich, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Brain Neoplasms / physiopathology*,  radionuclide imaging
Carbon Dioxide / diagnostic use
Cerebrovascular Circulation*
Glioblastoma / physiopathology*,  radionuclide imaging
Humans
Organometallic Compounds / diagnostic use*
Oximes / diagnostic use*
Oxygen Radioisotopes / diagnostic use*
Technetium / diagnostic use*
Technetium Tc 99m Exametazime
Tomography, Emission-Computed*
Chemical
Reg. No./Substance:
0/Organometallic Compounds; 0/Oximes; 0/Oxygen Radioisotopes; 100504-35-6/Technetium Tc 99m Exametazime; 124-38-9/Carbon Dioxide; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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