| Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: evaluation in patients treated with thrombolytic therapy for acute myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 9420778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Our segmentation algorithm for single-photon emission computed tomographic perfusion studies was tested in 244 patients treated by thrombolysis within 5 hours after onset of symptoms. This algorithm uses radial slices to approximate true three-dimensional gradients, determines the apex and basal plane, and creates a perfusion and volume polar map. METHODS AND RESULTS: Perfusion defect size was compared with enzymatic infarct size and global and regional function. All patients underwent rest planar and tomographic 99mTc-labeled sestamibi scanning, contrast coronary angiography, and ventriculography 10 to 14 days after the start of treatment. Manual correction had to be performed in only 10% of the cases and presented no problems. The correlation coefficients (r) between planar and relative tomographic perfusion defects versus enzymatic infarct size were 0.71 and 0.73. A negative correlation was found with left ventricular ejection fraction: r = -0.65 and r = -0.60. A comparable correlation was also found between regional wall motion and perfusion defect size. Most correlations were higher in the case of anterior infarction. An excellent correlation was found between planar and tomographic defect size (r = 0.83). CONCLUSIONS: In most cases, our segmentation algorithm delineates myocardial edges and basal plane automatically. A good correlation was found between perfusion defect size, enzymatic infarct size, and global and regional ventricular function. |
| | |
Authors:
|
L A Mortelmans; F J Wackers; J L Nuyts; I A Scheys; T Brzostek; C W Schiepers; E E Lesaffre; P L Suetens; A M Verbruggen; F J Van de Werf |
Related Documents
:
|
10329098 - Myocardial ischaemia in children with isolated ventricular non-compaction. 22475708 - Evaluation of an evidence-based practice implementation: prophylactic amiodarone follow... 22850138 - Associations of dietary calcium intake and calcium supplementation with myocardial infa... 21069488 - The role of myocardial perfusion imaging in evaluating patients with myocardial bridging. 7021998 - Urokinase therapy of subclavian-axillary vein thrombosis. 23407618 - Apply awaji-shima consensus conference criteria before diagnosing amyotrophic lateral s... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology Volume: 2 ISSN: 1071-3581 ISO Abbreviation: J Nucl Cardiol Publication Date: 1995 Mar-Apr |
Date Detail:
|
Created Date: 1998-02-09 Completed Date: 1998-02-09 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9423534 Medline TA: J Nucl Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 133-43 Citation Subset: IM |
Affiliation:
|
Department of Nuclear Medicine, University of Leuven, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Coronary Circulation* Female Heart / radionuclide imaging* Humans Male Middle Aged Myocardial Infarction / physiopathology, radionuclide imaging*, therapy Technetium Tc 99m Sestamibi / diagnostic use* Thrombolytic Therapy* Tomography, Emission-Computed, Single-Photon Ventricular Function, Left |
| Chemical | |
Reg. No./Substance:
|
109581-73-9/Technetium Tc 99m Sestamibi |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial iodine-labeled metaiodobenzylguanidine 123 uptake relates to age.
Next Document: Abnormal left ventricular ejection fraction response to mental stress and exercise in cardiomyopathy...