| Tomographic measurement of cerebral blood flow by the 68Ga-labelled-microsphere and continuous-C15O2-inhalation methods. | |
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MedLine Citation:
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PMID: 3930249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The measurement of cerebral blood flow (CBF) by continuous C15O2 inhalation has only been validated previously by indirect experimental protocols. In the present study using baboons, these measurements were compared directly with those obtained by injection of 68Ga-labelled serum-albumin microspheres in the left cardiac ventricle. Using a modified labelling technique, no elution of 68 Ga occurred in vivo. Both methods provided similar regional CBF values, which could be described by a significant linear correlation (CBFCO2 = 0.82 CBFmicrospheres + 5.7; P less than 0.001). The validity of the labelled-microsphere-injection method was verified. The feasibility of stable in vivo labelling of 68Ga to serum-albumin microspheres provides a reference method for organ blood-flow measurements using positron-emission tomography. |
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Authors:
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M Steinling; J C Baron; B Maziere; P Lasjaunias; C Loc'h; E A Cabanis; B Guillon |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 11 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-29 Completed Date: 1985-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 29-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Dioxide / diagnostic use* Carbon Radioisotopes / diagnostic use Cerebrovascular Circulation* Gallium Radioisotopes / diagnostic use* Microspheres Papio Serum Albumin / diagnostic use Tomography, Emission-Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Gallium Radioisotopes; 0/Serum Albumin; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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