| The Tomato Saponin, Esculeoside A. | |
| | |
MedLine Citation:
|
PMID: 20853874 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Esculeoside A (2), a spirosolane steroidal glycoside, is a major constituent isolated from Solanum lycopersicum, a commercial strain of mini tomatoes. The content variability of esculeoside A (2) was examined in mini, midi, and Momotaro tomatoes and various processed tomato products. In the green immature tomato fruit, tomatine (1) is oxidized at C-23 and C-27 to produce esculeoside A (2) in the ripe fruit. Further, esculeoside A (2) is partly converted to 3β-hydroxy-5α-pregn-16-en-20-one 3-O-β-lycotetraoside (6), a pregnane glycoside, in the overripe fruit. Esculeogenin A (3), the sapogenol of 2, is easily converted into 3β,16β-dihydroxy-5α-pregn-20-one (17). Metabolic studies showed excretion of androstane derivatives in the urine of human volunteer subjects after tomato consumption. Esculeogenin A (3) inhibited the accumulation of cholesterol esters in macrophages through its effects on acyl-CoA:cholesterol acyl transferase (ACAT). Oral administration of esculeoside A (2) to apoE-deficient mice significantly reduced serum levels of cholesterol, triglycerides, and LDL-cholesterol and ameliorated the severity of atherosclerotic lesions. |
| | |
Authors:
|
Toshihiro Nohara; Masateru Ono; Tsuyoshi Ikeda; Yukio Fujiwara; Mona El-Aasr |
Related Documents
:
|
4724834 - The effect of lecithin on intestinal cholesterol uptake by rat intestine in vitro. 2804054 - Reactivity of hdl subfractions towards lecithin-cholesterol acyltransferase. modulation... 10440574 - The lymphatic absorption of dihydrolanosterol and cholesterol in the rat. 2769074 - Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plas... 1889884 - Respiratory nicotine absorption in non-smoking females during passive smoking. 11589504 - Increased apoptosis in a variety of tissues of zinc-deficient rats. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-9-20 |
Journal Detail:
|
Title: Journal of natural products Volume: - ISSN: 1520-6025 ISO Abbreviation: - Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Faculty of Pharmaceutical Sciences, Sojo University, 22-1, 4-Chome, Ikeda, Kumamoto 860-0082, Japan, School of Agriculture, Tokai University, 5435, Aso, Kumamoto 869-1404, Japan, Graduate School of Pharmaceutical Sciences, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan, and Graduate School of Medical Sciences, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquiti...
Next Document: Lignans and Triterpenes from the Bark of Durio carinatus and Durio oxleyanus.