| Tolvaptan Improves Left Ventricular Dysfunction after Myocardial Infarction in Rats. | |
| | |
MedLine Citation:
|
PMID: 22984091 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: -Arginine vasopressin (AVP), which promotes the reabsorption of renal water is increased in chronic heart failure. Here, we compared the effects of tolvaptan, a newly developed non-peptide V(2) receptor antagonist, with those of furosemide, a loop diuretic, and a combination of these 2 agents in rats with left ventricular (LV) dysfunction after myocardial infarction (MI). METHODS AND RESULTS: -After 10 week of MI induction, rats were separated them into the following 6 groups adjusted to the infarct size: a vehicle group, a group treated with 15 mg·kg(-1)·day(-1) of furosemide; 2 groups treated with 3 or 10 mg·kg(-1)·day(-1) of tolvaptan, and 2 groups treated with 15 mg·kg(-1)·day(-1) of furosemide plus 3 or 10 mg(-)·kg(-1)·day(-1) tolvaptan. Each treatment agent was administered for 4 weeks, and all groups had similar blood pressure levels and infarct size. The tolvaptan-treated groups were found to have lower levels of LV end-diastolic and systolic cardiac volumes than the vehicle group. Furthermore, the improvement in the ejection fraction in the tolvaptan-treated groups was significantly greater than those in the vehicle group. ED-1 immunostaining and Sirius red staining revealed that tolvaptan significantly repressed MI-induced macrophage infiltration and interstitial fibrosis in the left ventricle, respectively. Tolvaptan attenuated the MI-induced mRNA expressions of atrial and brain natriuretic peptides, monocyte chemotactic protein-1, transforming growth factor-β1, AVP V(1a) receptor, and endothelin-1 in the marginal infarct region. CONCLUSIONS: -Tolvaptan may improve cardiac dysfunction after MI, which is partially mediated by the suppression of V(1a) receptor, neurohumoral activation and inflammation. |
| | |
Authors:
|
Takanori Yamazaki; Yasukatsu Izumi; Yasuhiro Nakamura; Naoto Yamashita; Hiroyuki Fujiki; Mayuko Osada-Oka; Masayuki Shiota; Akihisa Hanatani; Kenei Shimada; Hiroshi Iwao; Minoru Yoshiyama |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-9-14 |
Journal Detail:
|
Title: Circulation. Heart failure Volume: - ISSN: 1941-3297 ISO Abbreviation: Circ Heart Fail Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-9-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101479941 Medline TA: Circ Heart Fail Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1 Osaka City University Medical School, Osaka, Japan; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Effects of Different Attentional Demands in the Identification of Emotional Facial Expressions i...
Next Document: Integrating Quality Improvement Into Continuing Medical Education Activities Within a Community Hosp...