| Toluene and styrene intoxication route in the rat cochlea. | |
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MedLine Citation:
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PMID: 10440486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is well established that organic solvents such as toluene and styrene are ototoxic in the rat; however, the intoxication route used to reach the organ of Corti is still questionable. The distribution of toluene and styrene in various tissues of Long-Evans rats (n = 2 x 8) was studied after inhalation of either 1750 ppm toluene or 1750 ppm styrene for 10 h (6 consecutive h + 4 h the following day). At the end of the solvent exposures, blood, brain, auditory nerves, the organ of Corti, cerebrospinal (CSF), and inner ear fluids (IEF) were sampled or removed to measure the rates of solvent uptake in each tissue by gas chromatography. Results indicate that CSF and IEF were free from detectable solvents, whereas the organ of Corti, the nerves, and the brain were contaminated. Therefore, both toluene- and styrene-induced hearing losses are caused by tissue intoxication rather than by fluid contamination. It is proposed that the outer sulcus is used as an intoxication route to reach the organ of Corti. |
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Authors:
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P Campo; G Loquet; V Blachère; M Roure |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neurotoxicology and teratology Volume: 21 ISSN: 0892-0362 ISO Abbreviation: Neurotoxicol Teratol Publication Date: 1999 Jul-Aug |
Date Detail:
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Created Date: 1999-10-14 Completed Date: 1999-10-14 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 8709538 Medline TA: Neurotoxicol Teratol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 427-34 Citation Subset: IM |
Affiliation:
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Institut National de Recherche et de Sécurité, Laboratoire Multinuisances, Vandoeuvre, France. campo@inrs.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Animals Brain / metabolism Chromatography, Gas Cochlea / drug effects* Male Organ of Corti / metabolism* Rats Rats, Long-Evans Styrene / blood, cerebrospinal fluid, pharmacokinetics* Toluene / blood, cerebrospinal fluid, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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100-42-5/Styrene; 108-88-3/Toluene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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