Document Detail


Toll-like receptors in the uterus, cervix, and placenta: is pregnancy an immunosuppressed state?
MedLine Citation:
PMID:  17826427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: These studies were performed to elucidate the expression of Toll-like receptors (TLRs) in the uterus, cervix, and placenta in pregnancy and across gestation. STUDY DESIGN: Message expressions of TLR-2, -3, -4, and -9 were investigated in nonpregnant mice and across gestation in CD-1 mice. Uterine, cervical, and placental tissues were harvested, and RNA was extracted. Quantitative polymerase chain reaction was performed. RESULTS: Messenger RNA expression of TLRs is significantly upregulated in pregnant uterine and cervical tissues. There is differential TLR messenger RNA expression between the uterus, cervix, and placenta. In the placenta, TLR 4 is significantly downregulated. CONCLUSION: These findings suggest that the innate immune system is a dynamic system during gestation. The concept of immunosuppression during pregnancy appears to be valid in the placenta only in regard to TLR expression. Research is warranted to determine whether the upregulation in the uterus and cervix during pregnancy is associated with an increased likelihood of responding to a pathogen or serve as a protective mechanism or both.
Authors:
Juan M Gonzalez; Hua Xu; Ella Ofori; Michal A Elovitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  197     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-09-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296.e1-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Center for Research in Reproduction and Women's Health, University of Pennsylvania, Philadelphia, PA, USA. jugonzalez@obgyn.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cervix Uteri / immunology*
Female
Immune Tolerance / immunology*
Mice
Placenta / immunology*
Pregnancy
Toll-Like Receptor 2 / biosynthesis
Toll-Like Receptor 3 / biosynthesis
Toll-Like Receptor 4 / biosynthesis
Toll-Like Receptor 9 / biosynthesis
Toll-Like Receptors / biosynthesis*,  immunology
Uterus / immunology*
Chemical
Reg. No./Substance:
0/TLR3 protein, mouse; 0/Tlr2 protein, mouse; 0/Tlr4 protein, mouse; 0/Tlr9 protein, mouse; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 3; 0/Toll-Like Receptor 4; 0/Toll-Like Receptor 9; 0/Toll-Like Receptors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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