Document Detail

Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.
MedLine Citation:
PMID:  21306913     Owner:  NLM     Status:  MEDLINE    
Studies over the past decade have demonstrated a key role for pattern recognition receptors in the activation of autoreactive B cells. Self reactive B cells that manage to escape negative selection often express relatively low affinity receptors for self antigens (ignorant B cells), and can only be activated by integrating a relatively weak BCR signal with signals from additional receptors. Members of the toll-like receptor (TLR) gene family, and especially the nucleic acid binding receptors TLR 7, 8 and 9, appear to play a key role in this regard and promote the production of autoantibodies reactive with DNA- or RNA-associated autoantigens. These autoantibodies are able to form immune complexes with soluble or cell-bound ligands, and these immune complexes can in turn activate a second round of proinflammatory cells that further contribute to the autoimmune disease process. Recent data have emerged showing a pathogenic role for TLR7, with an opposing, protective role for TLR9. Targeting these disregulated pathways offers a therapeutic opportunity to treat autoimmune diseases without crippling the entire immune system. Further understanding of the role of specific receptors, cell subsets, and inhibitory signals that govern these TLR-associated pathways will enable future therapeutics to be tailored to specific categories of autoimmune disease.
Nathaniel M Green; Ann Marshak-Rothstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in immunology     Volume:  23     ISSN:  1096-3618     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-04     Completed Date:  2011-06-16     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-12     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Autoantibodies / immunology
B-Lymphocytes / immunology*
Interferon Type I / immunology
Lymphocyte Activation*
Toll-Like Receptors / genetics,  immunology*
Grant Support
P01 AR050256/AR/NIAMS NIH HHS; P01 AR050256-09/AR/NIAMS NIH HHS; R01 AR035230/AR/NIAMS NIH HHS; R01 AR035230-24/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Autoantibodies; 0/Interferon Type I; 0/Toll-Like Receptors

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