| Toll-like receptor driven B cell activation in the induction of systemic autoimmunity. | |
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MedLine Citation:
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PMID: 21306913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies over the past decade have demonstrated a key role for pattern recognition receptors in the activation of autoreactive B cells. Self reactive B cells that manage to escape negative selection often express relatively low affinity receptors for self antigens (ignorant B cells), and can only be activated by integrating a relatively weak BCR signal with signals from additional receptors. Members of the toll-like receptor (TLR) gene family, and especially the nucleic acid binding receptors TLR 7, 8 and 9, appear to play a key role in this regard and promote the production of autoantibodies reactive with DNA- or RNA-associated autoantigens. These autoantibodies are able to form immune complexes with soluble or cell-bound ligands, and these immune complexes can in turn activate a second round of proinflammatory cells that further contribute to the autoimmune disease process. Recent data have emerged showing a pathogenic role for TLR7, with an opposing, protective role for TLR9. Targeting these disregulated pathways offers a therapeutic opportunity to treat autoimmune diseases without crippling the entire immune system. Further understanding of the role of specific receptors, cell subsets, and inhibitory signals that govern these TLR-associated pathways will enable future therapeutics to be tailored to specific categories of autoimmune disease. |
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Authors:
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Nathaniel M Green; Ann Marshak-Rothstein |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in immunology Volume: 23 ISSN: 1096-3618 ISO Abbreviation: Semin. Immunol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-06-16 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: England |
Other Details:
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Languages: eng Pagination: 106-12 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA. nmgreen@bu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantibodies / immunology Autoimmunity* B-Lymphocytes / immunology* Humans Interferon Type I / immunology Lymphocyte Activation* Toll-Like Receptors / genetics, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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P01 AR050256-09/AR/NIAMS NIH HHS; R01 AR035230/AR/NIAMS NIH HHS; R01 AR035230-24/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Interferon Type I; 0/Toll-Like Receptors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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