Document Detail


Toll-like receptor 8 polymorphism and coronary artery disease.
MedLine Citation:
PMID:  18985439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toll-like receptors (TLRs) play roles in innate and adaptive immune responses. Some TLRs are involved in the pathogenesis of cardiovascular diseases. Coronary artery disease (CAD) has an inflammatory and immunological basis. We investigated whether TLR8 Met1Val and TLR8-129G>C single nucleotide polymorphisms (SNPs rs3764879 and rs3764880) are associated with CAD in the Chinese population. We enrolled 412 consecutive patients (185 with coronary stenosis >/=50% or previous myocardial infarction and 227 controls). Ligase detection reaction was performed to detect SNPs rs3764879 and rs3764880 of TLR8. The SNP at rs3764879 is in complete linkage disequilibrium with rs3764880. No significant difference was found in genotypic or allelic frequencies of these two common SNPs between CAD cases and controls (P > 0.05, respectively). No associations existed between these two SNPs and the severity of coronary artery stenosis (All P > 0.05). These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.
Authors:
Zhong Chen; Genshan Ma; Qi Qian; Yuyu Yao; Yi Feng; Chengchun Tang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-05
Journal Detail:
Title:  Molecular biology reports     Volume:  36     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1897-901     Citation Subset:  IM    
Affiliation:
Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, No. 87 Dingjiaqiao, Hunan Road, Nanjing, People's Republic of China. zhongchen7498@sina.com.cn
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Case-Control Studies
Coronary Artery Disease / genetics*
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Phenotype
Polymorphism, Single Nucleotide / genetics*
Sex Characteristics
Toll-Like Receptor 8 / genetics*
Chemical
Reg. No./Substance:
0/TLR8 protein, human; 0/Toll-Like Receptor 8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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