Document Detail


Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever.
MedLine Citation:
PMID:  20674764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever. The clinical course and outcome of the CCHF infection are different in humans. Toll-like receptors (TLRs) are a family of pathogen recognition receptors. TLR8 and TLR9 contribute to the recognition of viruses. We investigated frequency of TLR8 Met1Val, TLR8 -129C/G, TLR9 -1486T/C and TLR9 2458G/A polymorphisms in CCHF patients and healthy controls. Our study was conducted between June 1 and August 31, 2007 in Cumhuriyet University Hospital, Turkey. TLR genotypes were detected using the PCR-RFLP assay in 85 CCHF patients and 171 healthy controls. We found that heterozygous plus homozygous mutant genotypes frequency for TLR8 Met1Val and for TLR9 -1486T/C were significantly higher in CCHF patients than controls (p = 0.038 and p = 0.009, respectively). The frequency of TLR8 -129G/G genotype in the fatal CCHF patients was significantly higher than that of the non-fatal patients (p = 0.026). The frequency of TLR9 -1486C/C genotype was significantly higher in fatal CCHF patients than in healthy controls (p = 0.009) and in patients with severe disease compared to non-severe disease (p = 0.044). Our findings suggest that TLR8 Met1Val, TLR8 -129C/G, and TLR9 -1486T/C polymorphisms are important on clinical course of CCHF disease.
Authors:
Aynur Engin; Serdal Arslan; Sibel Kizildag; Hasret Oztürk; Nazif Elaldi; Ilyas Dökmetas; Mehmet Bakir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-30
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  12     ISSN:  1769-714X     ISO Abbreviation:  Microbes Infect.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-01-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1071-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.
Affiliation:
Department of Infectious Diseases, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey. aynurum2000@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Female
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Hemorrhagic Fever, Crimean / genetics*,  immunology*
Humans
Male
Middle Aged
Polymerase Chain Reaction / methods
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Toll-Like Receptor 8 / genetics*
Toll-Like Receptor 9 / genetics*
Turkey
Chemical
Reg. No./Substance:
0/TLR8 protein, human; 0/TLR9 protein, human; 0/Toll-Like Receptor 8; 0/Toll-Like Receptor 9

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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