| Toll-like receptor 8 and 9 polymorphisms in Crimean-Congo hemorrhagic fever. | |
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MedLine Citation:
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PMID: 20674764 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever. The clinical course and outcome of the CCHF infection are different in humans. Toll-like receptors (TLRs) are a family of pathogen recognition receptors. TLR8 and TLR9 contribute to the recognition of viruses. We investigated frequency of TLR8 Met1Val, TLR8 -129C/G, TLR9 -1486T/C and TLR9 2458G/A polymorphisms in CCHF patients and healthy controls. Our study was conducted between June 1 and August 31, 2007 in Cumhuriyet University Hospital, Turkey. TLR genotypes were detected using the PCR-RFLP assay in 85 CCHF patients and 171 healthy controls. We found that heterozygous plus homozygous mutant genotypes frequency for TLR8 Met1Val and for TLR9 -1486T/C were significantly higher in CCHF patients than controls (p = 0.038 and p = 0.009, respectively). The frequency of TLR8 -129G/G genotype in the fatal CCHF patients was significantly higher than that of the non-fatal patients (p = 0.026). The frequency of TLR9 -1486C/C genotype was significantly higher in fatal CCHF patients than in healthy controls (p = 0.009) and in patients with severe disease compared to non-severe disease (p = 0.044). Our findings suggest that TLR8 Met1Val, TLR8 -129C/G, and TLR9 -1486T/C polymorphisms are important on clinical course of CCHF disease. |
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Authors:
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Aynur Engin; Serdal Arslan; Sibel Kizildag; Hasret Oztürk; Nazif Elaldi; Ilyas Dökmetas; Mehmet Bakir |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-30 |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: 12 ISSN: 1769-714X ISO Abbreviation: Microbes Infect. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-25 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: France |
Other Details:
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Languages: eng Pagination: 1071-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved. |
Affiliation:
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Department of Infectious Diseases, Cumhuriyet University, School of Medicine, 58140 Sivas, Turkey. aynurum2000@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Female Gene Frequency Genetic Predisposition to Disease* Genotype Hemorrhagic Fever, Crimean / genetics*, immunology* Humans Male Middle Aged Polymerase Chain Reaction / methods Polymorphism, Genetic* Polymorphism, Restriction Fragment Length Toll-Like Receptor 8 / genetics* Toll-Like Receptor 9 / genetics* Turkey |
| Chemical | |
Reg. No./Substance:
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0/TLR8 protein, human; 0/TLR9 protein, human; 0/Toll-Like Receptor 8; 0/Toll-Like Receptor 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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