Document Detail


Toll-like receptor 5 activation promotes migration and invasion of salivary gland adenocarcinoma.
MedLine Citation:
PMID:  20819129     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
J Oral Pathol Med (2011) 40: 187-193 Background:  Toll-like receptor (TLR) signaling has been found to be closely associated with tumor development. The aim of this study was to examine whether activation of TLRs promote migration and invasion of salivary gland adenocarcinoma. Materials and Methods:  TLR expression in SGT and HSG cells was examined by RT-PCR. Wound scratch and chemotaxis cell migration assay were performed. Invasiveness was determined by Matrigel invasion assay. Results:  All the tested TLRs including TLR1, TLR2, TLR4, and TLR5 and myeloid differentiation factor-2 (MD-2) were expressed on SGT and HSG cells. Treatment of flagellin, but not Pam(3) CSK(4) and LPS, led to the production of IL-6 and IL-8, suggesting TLR5 is functional in both cells. Stimulation by flagellin also accelerated wound closure of SGT and HSG cells in a dose-dependent manner. In addition, flagellin promoted migration and invasion ability of SGT cells. Blocking of TLR5 using antibody restored the promoting effect of flagellin on migration and invasion of SGT cells. Conclusion:  These findings suggest that TLR5 activation by flagellin can promote migration and invasion of salivary gland adenocarcinoma.
Authors:
Jong-Hwan Park; Hyo-Eun Yoon; Dong-Jae Kim; Soo-A Kim; Sang-Gun Ahn; Jung-Hoon Yoon
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Publication Detail:
Type:  Journal Article     Date:  2010-08-31
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  40     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  187-93     Citation Subset:  D; IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Korea Department of Pathology and Research Center for Oral Disease Regulation of the Aged, School of Dentistry, Chosun University, Gwangju, Korea Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA Department of Biochemistry, College of Oriental Medicine, Dongguk University, Gyungju, Korea.
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