Document Detail


Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions.
MedLine Citation:
PMID:  17101559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Atherosclerosis is considered to be a chronic inflammatory disease. Toll-like receptor 4 (TLR-4), a key mediator in activating inflammatory cascade, has an A-to-G functional polymorphism that changes aspartic acid to glycine at position 299. TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis. MATERIAL AND METHODS: The study comprised autopsy material from 657 men (the Helsinki Sudden Death Study; mean age 53, range 33-70 years). RESULTS: Fewer G-allele carriers had 3-vessel coronary artery disease compared with AA homozygotes (OR 0.32; 95 % CI, 0.12-0.88, p = 0.027), and they also had a lower mean value for maximal coronary stenosis (p = 0.019). TLR-4 polymorphism was not significantly associated with the occurrence of acute or old myocardial infarction (MI). CONCLUSIONS: The G allele of the TLR-4 gene, which is associated with a lower inflammation response, was associated with a lower risk of coronary stenosis but not with the occurrence of MI and hence is not a major factor in the development of coronary atherosclerosis.
Authors:
J Hernesniemi; T Lehtimäki; R Rontu; M S Islam; C Eklund; J Mikkelsson; E Ilveskoski; O Kajander; S Goebeler; L E Viiri; M Hurme; P J Karhunen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  66     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-01-11     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  667-75     Citation Subset:  IM    
Affiliation:
Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Finland. jussi.hernesniemi@uta.fi
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Comorbidity
Coronary Stenosis / epidemiology,  genetics*,  pathology
Death, Sudden, Cardiac / epidemiology,  etiology*,  pathology
European Continental Ancestry Group / genetics
Finland / epidemiology
Humans
Male
Middle Aged
Myocardial Infarction / epidemiology,  genetics*,  pathology
Polymorphism, Genetic*
Toll-Like Receptor 4 / genetics*
Chemical
Reg. No./Substance:
0/TLR4 protein, human; 0/Toll-Like Receptor 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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