| Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions. | |
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MedLine Citation:
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PMID: 17101559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Atherosclerosis is considered to be a chronic inflammatory disease. Toll-like receptor 4 (TLR-4), a key mediator in activating inflammatory cascade, has an A-to-G functional polymorphism that changes aspartic acid to glycine at position 299. TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis. MATERIAL AND METHODS: The study comprised autopsy material from 657 men (the Helsinki Sudden Death Study; mean age 53, range 33-70 years). RESULTS: Fewer G-allele carriers had 3-vessel coronary artery disease compared with AA homozygotes (OR 0.32; 95 % CI, 0.12-0.88, p = 0.027), and they also had a lower mean value for maximal coronary stenosis (p = 0.019). TLR-4 polymorphism was not significantly associated with the occurrence of acute or old myocardial infarction (MI). CONCLUSIONS: The G allele of the TLR-4 gene, which is associated with a lower inflammation response, was associated with a lower risk of coronary stenosis but not with the occurrence of MI and hence is not a major factor in the development of coronary atherosclerosis. |
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Authors:
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J Hernesniemi; T Lehtimäki; R Rontu; M S Islam; C Eklund; J Mikkelsson; E Ilveskoski; O Kajander; S Goebeler; L E Viiri; M Hurme; P J Karhunen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 66 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-11-14 Completed Date: 2007-01-11 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: Norway |
Other Details:
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Languages: eng Pagination: 667-75 Citation Subset: IM |
Affiliation:
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Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Finland. jussi.hernesniemi@uta.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Comorbidity Coronary Stenosis / epidemiology, genetics*, pathology Death, Sudden, Cardiac / epidemiology, etiology*, pathology European Continental Ancestry Group / genetics Finland / epidemiology Humans Male Middle Aged Myocardial Infarction / epidemiology, genetics*, pathology Polymorphism, Genetic* Toll-Like Receptor 4 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/TLR4 protein, human; 0/Toll-Like Receptor 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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