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Toll-like receptor 2 is partially involved in the activation of murine astrocytes by Streptococcus suis, an important zoonotic agent of meningitis.
MedLine Citation:
PMID:  21429596     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The murine astrocyte response to virulent Streptocuccus suis, a swine and an emerging human meningitis-causing pathogen, is reported. Albeit astrocytes do not internalize S. suis, all S. suis strains studied enhanced Toll-like receptor (TLR)2 expression and the production of pro-inflammatory cytokines and inducible nitric oxide synthase. Cell wall components and hemolysin (suilysin) are shown to be mainly responsible for cell activation. Astrocytes from TLR2 knockout mice presented a partial but significant reduction of S. suis-induced production of pro-inflammatory cytokines. These results contribute to increase the knowledge on mechanisms underlying S. suis inflammation in the brain.
Authors:
Han Zheng; María C Domínguez Punaro; Mariela Segura; Claude Lachance; Serge Rivest; Jianguo Xu; Mathieu Houde; Marcelo Gottschalk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-21
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  -     ISSN:  1872-8421     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping, Beijing, China.
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